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FPL-55712-derived compounds

FPL-55712- or the leukotriene D4-derived sets of antagonists. It was developed from a weak lead, compound (19) (IC50 = 14 pM versus LTD, on guinea pig ileum). Replacement of the benzoic acid group with a chromanone carboxylic acid (similar to that found in FPL-55712) resulted in an analog that dis-... [Pg.224]


See other pages where FPL-55712-derived compounds is mentioned: [Pg.203]    [Pg.221]    [Pg.203]    [Pg.221]    [Pg.142]   
See also in sourсe #XX -- [ Pg.221 ]




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