Major histocompatability gene complex

In this section, we shall review the data that have demonstrated genetic restrictions of T-B lymphocyte interactions and of the interactions between macrophages and T lymphocytes. The conclusion we draw from these findings is that the development of functional T cells and the regulatory role of T lymphocytes in immune responses, which appears to be related to control of differentiation processes of other lymphocytes of both T and B classes, is mediated via molecules that are comprised, at least in part, of gene products of the major histocompatibility gene complex expressed on the surface membranes of such cells. 

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

Group of transmembrane proteins engaged in the presentation of small peptide fragments to T-cells. Two classes of Major histocompatibility complex (MHC) molecules exist both of which are encoded by a highly polymorphic gene cluster. MHC class I and class II proteins present peptide fragments to CD8+ and CD4+ T-cells, respectively. The human MHC is also known as HLA, the murine MHC as H-2 complex. 

Hamet, P., Tremblay, J., Malo, D., Kunes, J., Hashimoto, T. (1990b). Genetic hypertension is characterized by the abnormal expression of a gene localized in major histocompatibility complex hsp70. Transplant. Proc. 22,2566-2567. 

Sargent, C.A., Dunhan, 1., Trowsdale, J., Campbell, R.D. (1989). Human major histocompatibility complex contains genes for the major heat shock protein hsp70. Proc. Natl. Acad. Sci. USA 86, 1968-1972. 

Human leukocyte antigens (HLA) Groups of genes found on the major histocompatibility complex, which contain cell-surface antigen-presenting proteins. The body uses HLA to distinguish between self-cells and non-self-cells. 

Else, KJ., Wakelin, D., Wassom, D.L. and Hauda, KM. (1990a) The influence of genes mapping within the major histocompatibility complex on resistance to Trichuris muris infections in mice. Parasitology 101, 61-67. 

Homo sapiens (compared to Drosophila melanogaster) Large-scale gene duplications with substantial expansion of genes involved in acquired immune response (B cells, T cells, major histocompatibility complex genes, cytokines, chemokines and their receptors), plasma proteases (complement and hemostatic proteins), proteins associated with apoptotic regulation and proteins related to neuronal network formation and electrical coupling... 

Penn, D.J. and Potts, W. K. (1998) How do major histocompatibility complex genes influence odor and mating preferences Adv.Immunol. 69, 411—436. 

Thornhill, R., Gangestad, S.W., Miller, R., Scheyd, G., McCollough, J.K. and Franklin, M. (2003) Major histocompatibility complex genes, symmetry, and body scent attractiveness in men and women. Behav. Ecol. 14, 668-678. 

Landry, C., Garant, D., Duchesne, P. and Bematchez, L. (2001) Good genes as heterozygosity the major histocompatibility complex and mate choice in Atlantic salmon (Salrno salar). Proc. R. Soc. B 268, 1279-1285. 

Song, Z., et al., A novel cysteine-ridi sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex dass II genes via a repeated Cys-His domain and functions as a transcriptional repressor. / Exp Med, 1994, 180(5), 1763-74. 

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