Maintenance dose , calculation from

Give a loading dose or maintenance dose calculated from TC, Vd, and CL. 

When determining the dose of bicarbonate replacement, the goal for therapy is to achieve a normal serum bicarbonate level of 24 mEq/L (24 mmol/L). The dose is usually determined by calculating the base deficit [0.5 L/kg X (body weight)] x [(normal C02) - (measured C02)]. Because of the risk of volume overload resulting from the sodium load administered with bicarbonate replacement, the total base deficit should be administered over several days. Once the goal serum bicarbonate level is attained, a maintenance dose of bicarbonate is necessary and should be titrated to maintain serum bicarbonate levels. 

The prolonged dosing interval (if) or reduced maintenance dose (Df) is calculated from the following relationships, where Tn is the normal dosing interval and Dn is the normal dose ... 

If the patient s clinical response necessitates a change from the calculated loading dose of digoxin, then base calculation of the maintenance dose upon the amount actually given. 

If intermittent doses are given, the maintenance dose is calculated from ... 

In Equation 1.36, Dg is the adjusted maintenance dose for the patient with renal failure, D is the maintenance dose for a normal individual,/is the fraction excreted, and C/r is the patient s creatinine clearance, which can be determined from the serum creatinine value using the Cockcroft and Gault Equation 1.42. If a new dosing interval for the patient with renal failure (x ) is calculated, a reciprocal of the bracketed term in Equation 1.45 is used and the new equation becomes Equation 1.46. ... 

But our work is still not done In order to use either Eq. 12.45 or Eq. 12.30, a value for fmax, the time to peak at steady state from our oral regimen, is needed. This is calculated from Eq. 12.7, for which we know values of the absorption and the elimination rate constants. Once the time to peak at steady state for the oral regimen is calculated, we can work our way backwards Tmax allows calculation of (Oss)orai by Eq. 12.45 or 12.30 then having a value of (Oss)orai allows Calculation of tjv by Eq. 12.44. Finally tiv can be inserted into Eq. 12.43 and the equation solved for the new multiple intravenous bolus maintenance dose, (Dm)iv-... 

Dose estimates from other measured environmental samples are many orders of magnitude loiver than the estimates calculated in the previous sections for a concentration of 1 pCi m in air. The peak concentration of 2 pCi L as determined in milk samples near the Nuclear Fuel Services plant, would require maintenance of an air concentration of 1.7 X 10 pCi m , according to the model used above. Concentrations of in air around nuclear power plants are so much lower than those calculated for air around fuel processing facilities that they are essentially undetectable. 

Even, limited PSAs use and contain much information. This information may come as memos and process reports and flow sheets, equipment layout, system descriptions, toxic inventory, hazardous chemical reactions, test, maintenance and operating descriptions. From this, data and analyses are prepared regarding release quantities, doses, equipment reliability, probability of exposure, and the risk to workers, public, and environment. An executive summary analysis is detailed, and recommendations made for risk reduction. Thus the information will be text, calculations of envelope fracture stresses, temperatures, fire propagation, air dispersion, doses, and failure probabilities - primarily in tabular form. 

Baldessarini and Davis (1980) attempted to clarify whether there is a significant relationship between the antipsychotic maintenance dosages administered and the risk of relapse in the case of chronic schizophrenics. Correlations calculated for 23 controlled studies showed no relationship between the administered doses of antipsychotics and the risk of relapse within a wide range. Based on this result, the authors ruled that the maintenance dosage for each individual patient should be kept as low as possible in order to prevent antipsychotics from causing undesirable delayed effects. 

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