Maintenance dose, calculation

For the theophylline example given in Example Maintenance Dose Calculation, the loading dose would be 350 mg (35 L x 10 mg/L) for a 70-kg person. For most drugs, the loading dose can be given as a single dose by the chosen route of administration. 

Give a loading dose or maintenance dose calculated from TC, Vd, and CL. 

Skill Keeper Maintenance Dose Calculations (see Chapter 3)... 

When determining the dose of bicarbonate replacement, the goal for therapy is to achieve a normal serum bicarbonate level of 24 mEq/L (24 mmol/L). The dose is usually determined by calculating the base deficit [0.5 L/kg X (body weight)] x [(normal C02) - (measured C02)]. Because of the risk of volume overload resulting from the sodium load administered with bicarbonate replacement, the total base deficit should be administered over several days. Once the goal serum bicarbonate level is attained, a maintenance dose of bicarbonate is necessary and should be titrated to maintain serum bicarbonate levels. 

Once the number of maintenance doses (n) is entered the spreadsheet calculates Cp for the nth dosing interval. 

The prolonged dosing interval (if) or reduced maintenance dose (Df) is calculated from the following relationships, where Tn is the normal dosing interval and Dn is the normal dose ... 

The maintenance dose may be defined as the size of the dose required to maintain the therapeutic range according to the dosage regimen. The maintenance dose needed to replace the amount lost over the dosing interval is the difference between the loading dose and the amount remaining at the end of the interval. It is calculated as,... 

If rapid digitalization is considered medically appropriate, it may be achieved by administering a loading dose based upon projected peak digoxin body stores. Calculate maintenance dose as a percentage of the... 

If the patient s clinical response necessitates a change from the calculated loading dose of digoxin, then base calculation of the maintenance dose upon the amount actually given. 

To minimize the risk of induced arrhythmia, patients initiated or reinitiated on Betapace or Betapace AF should be placed for a minimum of 3 days (on their maintenance dose) in a facility that can provide cardiac resuscitation, continuous electrocardiographic monitoring, and calculations of creatinine clearance. For detailed instructions regarding dose selection and special cautions for people with renal impairment, see Administration and Dosage. 

Usual maintenance dose 1 to 5 mg/kg/day (maximum 200 mg/day in 1 or 2 divided doses). To achieve the usual maintenance dose, increase subsequent doses every 1 to 2 weeks as follows Calculate 0.3 mg/kg/day, round this amount down to the nearest whole tablet, and add this amount to the previously administered daily dose. 

The pediatrician calculates the dose based on the infant s weight, choosing the infant dose recommended in a pediatric pharmacology reference text. He prescribes a maintenance dose, given q.i.d. by mouth prior to scheduled feedings, and advises the... 

If intermittent doses are given, the maintenance dose is calculated from ... 

The following formula can be used to calculate maintenance dose... 

In the majority of clinical situations, drugs are administered as a series of repeated doses or as a continuous infusion in order to maintain a steady-state concentration. Therefore, a maintenance dose must be calculated such that the rate of input is equal to the rate of drug loss. This may be determined using the following formula ... 

European baseline SCIT dosage is lower than the US (this may account for some of the variability and higher ratios). SLIT/SCIT ratio = Sublingual immunotherapy monthly maintenance dose/subcutaneous monthly maintenance dose N/A = not available ssx = symptom scores meds = medication use. a Calculated dosages. 

Clearance (CL) is the volume of blood, plasma or serum cleared of drug per unit time. It relates the dosing rate to the average steadystate concentration (CsSay) and is used to calculate the maintenance dose of a drug. 

A third approach is to use the principles discussed previously to calculate a maintenance dose multiplication factor (MDMF) that can be used to augment the dose that would be appropriate in the absence of renal replacement therapy (32). For continuous renal replacement therapy, MDMF is given simply by the following ratio of clearances ... 

The steady-state trough (minimum effective) plasma concentration obtained after the administration of a maintenance dose is based on the volume of distribution, the fraction of dose remaining (fr = e T), and the fraction of dose eliminated (fei = 1 — e, t) during the dosage interval. Based on a desired trough plasma concentration (Cp ss(min)) at the end of the dosage interval, the maintenance dose that would be required may be calculated as follows ... 

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