Immunoglobulin-gene rearrangements

The repair of double-strand breaks is part of the physiologic process of immunoglobulin gene rearrangement. It... 

Lymphoid neoplasms are clone-expanded proliferations of cells representing distinct stages of B/T cell development. Immunoglobulin gene rearrangements can be detected to indicate monoclonality of B-cell lineage lymphoproliferative... 

CD 19, CD20 as well as immunoglobulin gene rearrangement, that induces speculations about the concept of lineage specificity. 

Ritchie, K.A., Brinster, R.L., Storb, U. (1984). Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in k transgenic mice. Nature 312,517-520. 

Toda, M., Hirama, T., Takeshita, S., Yamagishi, H. (1989). Excision products of immunoglobulin gene rearrangements. Immunol. Lett. 21, 311-316. 

This type of second strand management is found in eukaryotic transposable elements, such as the hAT group (28), and in V(D)J immunoglobulin-gene rearrangements (2) (Fig. Id). In these cases, however, hairpin formation occurs on the equivalent of the transposon flanks rather than on the transposon itself. In the case of V(D)J, no specific subterminal T exists, and in the case of the hAT transposons, the hairpin is formed on the transposon flank and can vary between different hAt copies. Thus, hairpin formation in these cases occurs on sequences that are not necessarily conserved, and it seems unlikely that it involves a specific flipped-out T residue. 

Molecular Genetic Basis for Immunoglobulin-Gene Rearrangements... 

Cheng GY, Minden MD, Toyonaga B, Mak TW, McCulloch EA. T cell receptor and immunoglobulin gene rearrangements in acute myeloblastic leukemia. 

Ha K, Minden M, Hozumi N, Gelfand EW. Immunoglobulin gene rearrangement in acute myelogenous leukemia. Cancer Res 1984 44 4658-60. 

The majority of these lymphomas demonstrate clonal immunoglobulin gene rearrangements. The most common cytogenetic abnormality identified in this lymphoma is deletions in the long arm of chromosome 6 (del(6)(q21)) with a small number of these lymphomas demonstrating t(9 14)(pl3 32). These translocations are not specific for lymphoplasmacytic lymphoma and have been demonstrated in other B-cell lymphomas. 

Fig. 1. Immunoglobulin gene rearrangement and expression. A highly simplified view of the mouse IgH locus is presented which is neither to scale nor are the full complements of gene segments depicted. The IgH enhancer is indicated by the symbol E.

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