Lutenizing hormone

HPLC High Performance Liquid Chromatography LHRH Lutenizing Hormone Releasing Hormone PTC Phase transfer catalyst SPPS Solid Phase Peptide Synthesis TFA Trifluoro acetic acid... 

Thyroid Effects. Limited information is available on thyroid effects in PBDE-exposed humans. There are suggestive occupational data as shown by effects that included increased serum FSH, low or borderline low serum T4, and increased thyroid antimicrosomal antibody titers in workers exposed to decaBDE and/or unspecified PBBs. There was no clear association between plasma levels of 2,2, 4,4-tetraBDE and thyroid hormone levels (free and total T3 and T4, TSH, free testosterone, follicle-stimulating hormone, lutenizing hormone, and prolactin) in men who consumed varying amounts of fatty fish from the Baltic Sea. Based on consistent evidence in animals, as summarized below, the thyroid is particularly sensitive to PBDEs and is a likely target of toxicity in exposed humans. 

Secretion of follicle-stimulating hormone (FSH) and lutenizing hormone (LH). 

Karanath S, Lyson K, Aguila MC, McCann SM. Effects of lutenizing-hormone-releasing hormone, alpha-melanocyte-stimulating hormone, naloxon, dexamethasone and indomethacin on interleukin-2-induced corticotropin-releasing factor release. Neuroimmunomodulation 1995 2(3) 166-173. 

Note LHRH = lutenizing hormone-releasing hormone L-PLA = L-poly(lactic acid) PLGA = poly(lactic-co-glycolic acid) PLA = poly(lactic acid) w/o/w = water/oil/water o/w = oil/water. 

Abbreviations IgGl. immunoglobulin Gl KLH, keyhole limpet hemocyanin BSA, bovine serum albumin RNase A. ribonuclease A LDH. lactate dehydrogenase MHC, major histocompatibility complex LHRH, luteneizing hormone releasing hormone CCK. cholecystokinin VIP. vasoactive intestinal peptide TASP, template-assembled synthetic proteins MAPS, multiple antigen presenting system SUV, small unilamellar vesicle DCC. dicyclohexylcarbodiimide HOSu. N-hydroxysuccinimide Mal>. maleimido TFA, trifluoroacelic acid TFE. triiluoroethanol DMF, dimethylformamide DMSO. 

Gs Lutenizing hormone Adenylyl cyclase Increase estrogen, progesterone synthesis... 

Lechan, R. M., Alpert, L. C., and Jackson, I. M. D., 1976, Synthesis of lutenizing hormone releasing factor and thyrotropin releasing factor in glutamate-lesioned mice. Nature 264 463-465. 

Leuprolide is a nonapeptide synthetic analog of lutenizing hormone-releasing hormone [1304]. The synthetic mixture and six impurities were separated in 16 min on a Cg column (A = 220 nm) using a 31/69/0.1 acetonhrile/water/TFA mobile phase. Plots of the effects of percent acetonitrile changes on selectivity were presented. Peak shapes were excellent and good resolution was achieved. Solutions were made up at the 1 mg/mL level. 

INEPT = Intensive Nuclear Enhancement by Polarization Transfer LHRH = Lutenizing Hormone Releasing Hormone M = Monomer... 

Controlled Release of Peptides and Proteins. Sustained release applications are especially useful for proteins/peptides because of their short half-lives (62). This concept was first utilized commercially in Lupron Depot, which was introduced as a sustained release formulation of a lutenizing hormone-releasing hormone (LHRH), leuprolide acetate, with poly(lactic acid) as the polymer (63). Following the success of Lupron Depot, other sustained release formulations of LHRH analogues have also been commercialized, including Zoladex wherein the LHRH peptide is encapsulated in PLA-extruded rods, and Trelstar depot wherein the peptide is encapsulated in PLGA polymer matrices. 

GalNAc-4-S04 Lutenizing hormone. Thyroid stimulating hormone ]6I] Urokinase [62] Chondroitin 4-sulfate ]56]... 

Lee, G., Aloj, S. M., and Kohn, L. D., 1977, The structure and function of glycoprotein hormone receptors Ganglioside interactions with lutenizing hormone, Biochem. Biophys. Res. Commun. 77 A3. ... 

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