Antibody antimicrosomal

During the thyrotoxic phase of painless thyroiditis, the 24-hour RAIU is suppressed to less than 2%. Antithyroglobulin and antimicrosomal antibody levels are elevated in more than 50% of patients. 

Thyroid Effects. Limited information is available on thyroid effects in PBDE-exposed humans. There are suggestive occupational data as shown by effects that included increased serum FSH, low or borderline low serum T4, and increased thyroid antimicrosomal antibody titers in workers exposed to decaBDE and/or unspecified PBBs. There was no clear association between plasma levels of 2,2, 4,4-tetraBDE and thyroid hormone levels (free and total T3 and T4, TSH, free testosterone, follicle-stimulating hormone, lutenizing hormone, and prolactin) in men who consumed varying amounts of fatty fish from the Baltic Sea. Based on consistent evidence in animals, as summarized below, the thyroid is particularly sensitive to PBDEs and is a likely target of toxicity in exposed humans. 

A potential biomarker of exposure to PBBs is related to their effect on the thyroid gland. As discussed in Sections 3.2.2.2, Endocrine Effects, the thyroid gland is an unequivocal target of PBBs in animals, and evidence in humans is suggestive of a similar relationship. Effects in workers exposed to unspecified PBBs and/or decabromobiphenyl included increased scrum thyrotropin, low or borderline low serum T4, and increased thyroid antimicrosomal antibody titers (Bahn et al. 1980). A spectrum of thyroid effects has been... 

Antimicrosomal antibodies Antithyroid peroxidase antibodies TSH receptor antibodies... 

The 24-hour RAIU wiU be suppressed to less than 2% during the thyrotoxic phase of painless thyroiditis. Antithyroglobuhn and antimicrosomal antibody levels are elevated in more than 50% of patients. Painless thyroiditis frequently occurs during the immediate postpartum period, and individual patients may experience recurrence of the disease with subsequent pregnancies. Patients with mild hyperthyroidism and painless thyroiditis should be reassured that they have a self-hmited disease. Adrenergic symptoms may be ameliorated with propranolol. Antithyroid drugs are not indicated because they do not decrease the release of preformed thyroid hormone. 

Physical examination revealed blood pressure 180/90 mm Hg, heart rate 110/min, minimal proptosis, and an enlarged thyroid gland. Laboratory tests showed elevated thyroxine, resin uptake, radioactive iodine uptake, and antimicrosomal antibodies. A diagnosis of hyperimmune hyperthyroidism (Graves disease) was made. 

Measurement of antimicrosomal antibody has been associated with a low specificity due to interfering factors, such as the presence ofTg in the purified microsomes or other antibodies also reacting with the thyroid microsomal fraction (Feldt-Rasmussen et al., 1991). The higher specificity and sensitivity of the newer assays have been shown in a number of studies (Arai et al., 2000 Kasagi et al., 1996 Feldt-Rasmussen et al., 1983 Lindberg et al., 2001 Roti etal., 1992). 

Mori T, Kriss JP. Measurements by competitive binding radioassay of serum antimicrosomal and antithyroglobuhn antibodies in Graves disease and other thyroid disorders. J Clin Endocrinol Metab 1971 33 688-98. 

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