A549 lung carcinoma cells

Bost, F., McKay, R., Dean, N., and Mercola, D., The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells, J. Biological Chem., 272, 33422-33429, 1997. 

Fig. 41.2 Cellular location and schematic representation of the apoptotic pathways activated by Berberine in tumor cells. Upper panels, berberine accumulates in the nucleus of A549 lung carcinoma cell line. Cells were incubated with berberine (50 pM) for the indicated times and, subsequently, nuclei were stained with the fluorescent dye DRAQ5. Images were taken in a Leica TCS SP2 confocal microscope. Pictures correspond to the central section in a confocal z-stack acquired sequentially. Green berberine Red DRAQ5 Grey DIC image. Lower panel, berberine activates in vitro the intrinsic cell death pathway. Berberine-induced apoptosis is initiated after DNA damage by cell cycle arrest in GO/Gl mediated by the ATM/p53 pathway. In addition, berberine is able to block cell cycle in G2M by activation the ATM/Chkl p53-independent pathway in some tumor cell types. Activation of these pathways leads to transcription (TF) of...

Dale IL, Gescher A (1989) Effects of activators of protein kinase C, induding bry-ostatins 1 and 2, on the growth of A549 human lung carcinoma cells. Int J Cancer 43 158-163... 

Chien, P.-S., O.-T. Mak, and H.-J. Huang. 2006. Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. Biochem. Biophys. Res. Commun. 339 562-568. 

Huang et al. (1999) reported successful isolation and identification of a sporadic HEV strain (G93-2) in human lung carcinoma cell (A549). Huang et al. (1999) made stem recommendations for the estabhshment of a propagation method for both sporadic and epidemic HEV strains in cell culture systems, the target being to facilitate vaccine research. 

Billich, A., Bornancin, F., Mechtcheriakova, D., Natt, F., Huesken, D., and Baumruker, T., IL-1 (3 and TNF-a induced production of inflammatory mediators in A549 epithelial lung carcinoma cells is dependent on sphingosine kinase 1 activity. Cell Signal, 17 (2005) 1203-1217. 

In NHI 3T3 fibroblasts bryostatin 1 showed similar potency to 12-0-tetradecanoylphorbol-13-ace-tate for translocating PKCa to the cell membrane but was a much more potent downregulator of PKCa activity than 12-0-tetradecanoylphorbol-13-acetate. It was also a much more potent translocator and downregulator of PKC8 and PKCe than 12-0-tetradecanoylphorbol-13-acetate (Szallasi et al. 1994). The compound inhibited the proliferation of human A549 lung carcinoma (Dale and Gescher... 

Human lung carcinoma cells (A549), 3480 Human myeloma cells (Human 8226), 991 Human protein tyrosine phosphatase IB (hPTPlB), 1211... 

CcR/CNT/PPy/Pt CcR/SAM-GNP/ PPy/Pt Cytochrome c CV 1-1000 nM 5-600nM Quantification of the mitochondrial cytochrome c released in cytosol of human lung carcinoma cells A549 upon induction of apoptosis with doxorubicin Pandiaraj et al. (2013)... 

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