Lung cancer curcumin

Chen YS, Ho CC, Cheng KC, Tyan YS, Hung CF, Tan TW, Chung JG. 2003b. Curcumin inhibited the arylamines N-acetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells (A549). Toxicol In Vitro 17 323— 333. 

Lee J, Im YH, Jung HH, Kim JH, Park JO, Kim K, Kim WS, Ahn JS, Jung CW, Park YS, Kang WK, Park K. 2005. Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. Biochem Biophys Res Commun 334 313-318. 

Radhakrishna Pillai G, Srivastava AS, Hassanein TI, Chauhan DP, Carrier E. 2004. Induction of apoptosis in human lung cancer cells by curcumin. Cancer Lett 208 163-170. 

Zhang J, Qi H, Wu C. 2004. Research of anti-proliferation of curcumin on A549 human lung cancer cells and its mechanism. Zhong Yao Cai 27 923-927. 

Hecht SS, Kenney PM, Wang M, Trushin N, Agarwal S, Rao AV, Upadhyaya P. 1999. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-l-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Lett 137 123-130. 

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. 2005. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11 7490-7498. 

From all these studies, it is clear that curcumin exhibits activities against cancer, cardiovascular diseases, and diabetes, the major ailments in the U.S. This dmg has also shown therapeutic effects against Alzheimer s disease, multiple sclerosis, cataract formation, HIV, and drag-induced nonspecific toxicity in the heart, lung, and kidney. Several of the studies estabhshing curcumin s potential were carried out in animals. Further testing of curcumin in humans is required to confirm these observations. A clinical development plan for using curcumin to treat cancer was recently described by the NCI. Studies also show that in countries such as India where curcumin is consumed. 

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