Reporting systems local

Self-reported staff reactions that would potentially be taken after the event may be stated as follows (1) keep the event to oneself, (2) report the event to one s leader or the doctor in charge, (3) report the event to the local reporting system, (4) write in the patient s case-record about the event, (5) inform the patient about the event and future risk, (6) ejq)lain to the patient that the event was eaused by one s mistake and (7) apologise about the event to the patient. 

These reports were in addition to the internal reporting for OSHA PSM and various local or state requirements. While Quality Chemical had long ago consolidated a number of these programs, there were still four different accident/incident reporting systems—one for external reporting of releases, one for external reporting of injuries and other nonrelease events, one for a corporate-wide database and one for each site itself. 

Oral corrosion of metallic restorations does not, per se, generally result in serious damage to the structure. Corrosion can result, however, in various local and systemic effects, notably the hypersensitivity and allergic reactions reported by many workers. Galvanic cells created by mixed metal couples can delay fracture healing and induce oral lesions and cancer. 

The Major Accident Reporting System (MARS) is a distributed information network, consisting of 15 local databases on a MS-Windows platform in each Member State of the European Union and a central UNIX-based analysis system at the European Commission s Joint Research Centre in Ispra (MAHB) that allows complex text retrieval and pattern analysis. 

The concept of a photo-release and report system has been realized with the 9-(2-methyl-l,3-dithien-2-yl)-9//-thioxanthen-9-ol tethered to a PAMAM dendrimer. Irradiation of the dendrimer system with a U-360 broadband filter results in cleavage of the dithienyl unit to generate, after hydrogen radical transfer, 2-methyl-l,3-dithiane and the tethered thioxanthone 630. The increased fluorescence of the latter confirms the successful photo cleavage. The system offers potential for the generation of high local concentrations of substituted dithianes in the vicinity of the dendrimer surface (Equation 209) <2005JA12458>. 

Antiseptics and antibiotics are the two hallmarks of antimicrobial therapy. Although there are several reports about local and systemic antimicrobials for therapy of eczematous skin diseases, there is only little data about prevention. 

Every laboratory should have an internal accident-reporting system. This includes provisions for investigating the cause of an injury as well as any potentially serious incident that does not result in injury. The primary aim of such investigations should be to make recommendations to improve safety, not to assign blame for an incident. Local legal regulations may require reporting procedures for accidents or injuries. 

The nature of organisation of the reporting system is it local (e.g, plant-based) or central (e.g. company-based) Is reporting voluntary or mandatory ... 

Many other drugs have been administered in the vagina for the management of either local or systemic conditions. Table 6 summarizes some of these reports. 

A small prospective clinical study of 6 patients with laboratory diagnosed Candida infections reported that all 6 patients responded to topical fluconazole therapy, with no local or systemic side effects, in an average of 22.6 days (Panda et al.). 

A small prospective study reported that 13 of 14 patients with severe fungal keratitis (Aspergillus, Pusarium, and Candida ) had resolution with subconjunctival fluconazole after failing to respond to topical and systemic fluconazole and itraconazole therapy. No local or systemic toxic side effects were reported (Yihnaz and Maden). 

The occurrence of epidemic diphtheria in Eastern Europe led to the recommendation in the UK that those aged 15-18 years should receive a combined tetanus and low-dose diphtheria toxoid vaccine instead of a tetanus booster alone. In March 1995, 220 children aged 14—16 years were inadvertently given high-dose diphtheria and tetanus toxoid vaccine, and their parents were sent a questionnaire 153 replied. A total of 141 (92%) of adolescents reported one or more reactions, most of which were classified as mild or moderate and lasted less than 1 week. However, 47 (31%) reported at least one severe local or systemic reaction (2). 

In 1983, Godec and Gleich reviewed all published results of treatment of intractable hematuria with formalin. Dilutions of 1-10% formalin (containing 0.37-3.7% formaldehyde) were used the most commonly used concentration of formalin was 10%. The authors concluded that formalin was probably the most effective tool for controlling massive hematuria, but also probably the most dangerous. The review covered 23 articles and 118 patients in 104 cases, treatment was successful. However, in only 10 reports had the treatment been used without serious adverse effects the other 13 articles listed four deaths and many serious local and systemic complications. The complication rate increased when the formalin concentration was higher, but the contact time and the volume instilled did not influence the occurrence of adverse effects. The most frequent local complications were reflux and hydronephrosis. Fibrosis of the bladder with reduced capacity was the usual clinical outcome. A systemic effect was tubular necrosis with anuria, with two deaths. Another complication was ureteric obstruction, which was not related to ureteric fibrosis or bladder wall fibrosis obstructing the intramural ureter in two cases the obstruction appeared to be due to retroperitoneal fibrosis (SEDA-11, 476) (4). 

Between 1988 and 1996, the Australian Drug Evaluation Committee received some 600 reports of suspected adverse events after hepatitis B immunization. There were no serious events, and the overwhelming majority were well-known mild-to-moderate local or systemic reactions (7). Musculoskeletal symptoms, such as arthralgia, arthritis, and myalgia, were mentioned in 106 reports. 

Systemic hypersensitivity reactions are not a frequent problem in local anesthesia. Systemic toxicity or allergy to additives (hyaluronidase, bisulfate, parabens) has sometimes been mistakenly classified as hypersensitivity to local anesthetics (SEDA-17,135) (29). WeU-documented case reports are very few, relating particularly to the older aminoesters this appears to be because these agents have the highly antigenic para-aminobenzoic acid as a metabolite (SEDA-13, 98). The incidence of true allergy is actually very low, probably less than 1% of all the adverse effects attributable to these substances (SEDA-20, 123). 

A combined meningococcal and typhoid vaccine (Merieux) was evaluated in 158 volunteers in a singleblind study (11). Comparing the effects with those in vaccinees receiving monocomponent vaccines or the combination vaccine, there was no significant difference in the reported frequency or duration of local and systemic reactions. However, vaccinees who received the monocomponent typhoid fever vaccine alone were less likely to complain of swelling or pain at the injection site. 

Skin tests are first applied as a prick test for safety. In the absence of a local or systemic reaction, an intradermal test is performed and interpreted as described elsewhere (181,182). Experience with skin testing in penicillin allergy has been reviewed (176,183). Properly performed sequential testing is considered a safe procedure, and only an estimated 1% or less of penicillin allergic patients will have systemic symptoms while undergoing skin tests. However, at least three deaths have been reported with both epicutaneous and intradermal testing (184). 

In 29 children aged 1-12 years with chronic liver disease who received one dose of Varicella vaccine, seroconversion rates at 8 weeks after immunization were 100% (21). The geometric mean titers tended to relate to the severity of liver disease. Local and systemic reactions did not differ from reactions reported in healthy children. 

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