Liver macrophages

Derksen, J. T. P. (1987). Immunoglobulin-coupled liposomes and their interaction with rat liver macrophages. Ph.D. Thesis. University of Groningen, The Netherlands. 

Daemen, T., Veninga, A., Dijkstra, J., and Scherphof, G. (1989) Differential effects of liposomeincorpo-ration on liver macrophage activating potencies of rough lipopolysaccharide, lipid A, and muramyl dipeptide Differences in susceptibility to lysosomal enzymes. Immunol. 142, 2469-2474. 

Gardner, C.R., Wasserman, A.J., and Laskin, D.L., Liver macrophage-mediated cytotoxicity toward mastocytoma cells involves phagocytosis of tumor targets, Hepatology, 14, 318, 1991. 

Macrophage scavenger receptor antigen Baird s beaked whale, short-finned pilot whale, Risso s dolphins, bottlenose dolphins, and pantropical spotted dolphins Liver macrophages Cross-reactive [101]... 

C3 and C5 Liver, macrophage C3 hinds to C42 complex to form C423 C5 hinds to C423 to form C4235 provides sites for C6 and C7... 

ElSisi, A.E., Earnest, D.L. Sipes, I.G. (1993b) Vitamin A potentiation of carbon tetrachloride hepatotoxicity role of liver macrophages and active oxygen species. Toxicol, appl. Pharmacol., 119, 295-301... 

K. Decker, Biologically active products of stimulated liver macrophages (Kupffer cells), Eur. J. Biochem. 792 245-261 (1990). 

M. Tomita, K. Yamamoto, H. Kobashi, M. Ohmoto, and T. Tsujii, Immunohisto-chemical phenotyping of liver macrophages in normal and diseased human liver. Hepatology 20 317-325 (1994). 

Daemen, T. Hofstede, G. Ten Kate, M.T. Bakker-Woudenberg, I.A. Scherphof, G.L. Liposomal doxorubicin-induced toxicity depletion and impairment of phagocytic activity of liver macrophages. Int. J. Cancer. 1995, 61, 716-721. 

The detailed characteristics of the uptake of plasmid DNA were examined using cultured cells. Various cells have the ability to take up plasmid DNA in a concentration- and temperature-dependent manner. One example involves the brain microvessel endothelial cells,17 which constitute the blood-brain barrier. However, their contribution to the tissue distribution of plasmid DNA seems to be minor. The main cells responsible for the distribution of plasmid DNA are immune cells such as macrophages. In fact, Kupffer cells, liver macrophages, make a large contribution to the clearance of plasmid DNA administered into the blood circulation. Plasmid DNA is efficiently taken up by cultured mouse peritoneal macrophages.18 The profile of uptake inhibition is similar to that observed in brain microvessel endothelial cells. Another population of immune cells is dendritic cells (DCs) these are very important as far as both innate and acquired immunity are concerned. The DC cell line (DC2.4 cells) exhibits extensive uptake and degradation of plasmid DNA.19... 

Roerdink F, Regts J, Daemen T, et al. Liposomes as drag carriers to liver macrophages. In Targeting of Drags with Synthetic Systems. New York Plenum Press, 1985 193. 

The acetyl-LDL receptor appears also to function in vivo. I-Labeled acetyl-LDL administered intravenously is cleared within minutes by liver macrophages [19,25]. Simultaneous injection of fucoidin blocks hepatic uptake [19], consistent with the in vitro specificity. While the physiological ligand for the acetyl-LDL receptor is not known, cultured endothelial cells convert human LDL to a form with decreased electrophoretic ability (possibly due to increased negative charge) that is taken up by macrophage acetyl-LDL receptors [65]. 

Gantner F, Leist M, Kiisters S, Vogt K, Volk D, Tiegs G (1996) T cell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release. Exp Cell Res 229 137-146... 

Murine liver macrophages D-Maimose, L-fucose, D-galactose and iV-acetyl-... 

Fichter M, Baier G, Dedters M, Pretsch L, Pietrzak-Nguyen A, Landfester K, et al. Nanocapsules generated out of a polymeric dexamethasone shell suppress the inflammatory response of liver macrophages. Nanomedicine 2013 9 1223-34. 

Derksen JTP, Moselt HWM, Scherphof GL (1988) Uptake and processing of immunoglobulin-coated liposomes by subpopulations of rat liver macrophages. Biochim Biophys Acta 971 127-136... 

In a similar experiment, EP-AG-activated Kupffer cells (liver macrophages) were cocultivated with Candida albicans cells and the Candida cells released from the lysed macrophages counted. 100 pg of EP-AG turned out to be as effective in activating the macrophages to inhibit growth of C. albicans as the maximal activation obtained by EPS and IFNy together [11]. 

---