The macrophage scavenger receptors Fig

Two pathways for the cellular uptake of plasma LDL have been the subject of intense investigation the native LDL-receptor pathway and the scavenger-receptor pathway. The native LDL-receptor pathway of endocytosis was discovered and has been characterized in great detail by Brown and Goldstein [89], By contrast the cell and molecular biology and the physiological 

The type II receptor (93) is identical to the type I receptor, except that the cysteine-rich domain (domain VI) is replaced by a six-residue C terminus. Despite this truncation, the type II receptor mediates endocytosis of chemically 

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