Macrophage-mediated cytotoxicity

Gardner, C.R., Wasserman, A.J., and Laskin, D.L., Liver macrophage-mediated cytotoxicity toward mastocytoma cells involves phagocytosis of tumor targets, Hepatology, 14, 318, 1991. 

CN185 Wallace, F. A., S. ]. Neely, E. A. Miles, and P. C. Calder. Dietary fats affect macrophage-mediated cytotoxicity towards tumour cells. Immunol Cell Biol 2000 78(1) 40-48. 

Higashi N, Taki H, Nishimura Y, et al. 1993. Chromium and tritiated thymidine releases from target cells are differential events in human monocyte/macrophage-mediated cytotoxicity. Cell Immunol 150 333-342. 

Herrmann D, Seitz G, Fuchs J, Armeanu-Ebinger S. Susceptibility of rhabdomyosarcoma cells to macrophage-mediated cytotoxicity. Oncoimmunology. 2012 1 279-86. 

Feng ZH, Zhang GM, Hao TL, Zhou B, Zhang H, Jiang ZY (1994) Effect of diallyl trisulfide on the activation of T-cell and macrophage-mediated cytotoxicity. J Tongji Med Univ 14 142-147... 

Macrophage Activation - The role of macrophages in tumor rejection is being actively investigated. Certain compounds which exhibit antitumor activity has been shown to act via the macrophage, probably through macrophage-mediated cytotoxicity. include endotoxin and double... 

Lefkowitz DL, Mills K, Castro A, Lefkowitz SS. Induction of tumor necrosis factor and macrophage-mediated cytotoxicity by horseradish peroxidase and other glycosylated proteins. J Leukoc Biol 1991 50 615-623. 

Montavani, A., et. al., Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on macrophage and natural killer cell-mediated cytotoxicity in mice, Biomedicine, 32, 200, 1980. 

Macrophages Nonspecific, direct killing of target by phagocytosis also involved in presenting antigen to specific Tk cells that can then mediate cytotoxicity as described above. 

About 10 days after transplantation, acute rejection of the graft begins as a result of cell-mediated immunity. Acute rejection is a result of infiltration of large numbers of macrophages and lymphocytes into the graft. Helper T-cell activation and proliferation play a major role in this process, and both complement-dependent cell-mediated cytotoxicity and ADCC are involved in the destruction of the graft. Acute rejection could be in the form of acute vascular rejection, acute cellular rejection or both. Acute vascular rejection involves the necrosis of the blood vessel cells of the graft... 

Fig. 9.3. Immunoglobulin E (IgE) and mast cell activation are important components of the mammalian response to cestode infections (ADCC, antibody dependent cell-mediated cytotoxicity Ag, antigen EO, eosinophils Feel, high affinity receptor for Fc portion of IgE LTs, leukotrienes Mac, macrophages NO, nitric oxide PGs, prostaglandins TNFa, tumour necrosis factor alpha).

Feng, B., Rollo, E.E. and Denhardt, D.T. (1995) Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity evidence from cell lines down-regulated for OPN expression by a targeted ribozyme. Clin. Exp. Metastasis, 13, 453 162. 

Two types of immunity may be induced in response to an antigen, namely humoral immunity mediated by antigen-specific antibodies produced by B lymphocytes, and cell-mediated immunity produced by activated macrophages and cytotoxic T lymphocytes. Antibodies may neutralize pathogens, whereas... 

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