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Liquid chromatography ultra-performance/pressure

Lerma-Garcia, M. J., Simo-Alfonso, E. R, Mendez, A., Lhberia, J. L., and Herrero-Martmez, J. M. 2010. Fast separation and determination of sterols in vegetable oils by ultra-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry detection. J. Agric. Food Chem. 58 2771-2776. [Pg.240]

Remane D, Meyer MR, Wissenbach DK, Maurer HH (2010) Ion suppression and enhancement effects of co-eluting analytes in multi-analyte approaches systematic investigation using ultra-high-performance liquid chromatography/mass spectrometry with atmospheric-pressure chemical ionization or electrospray ionization. Rapid Commun Mass Spectrom 24(21) 3103— 3108. doi 10.1002/rcm.4736... [Pg.194]

Keywords Pressurized liquid extraction supercritical fluid extraction ultra-sound-assisted extraction microwave-assisted extraction matrix solid-phase extraction high-performance liquid chromatography gas chromatography liquid-liquid extraction solid phase extraction column chromatography... [Pg.25]

It was indicated that most detectors used in high-pressure liquid chromatography are optical detectors that use ultra violet, visible or laser light sources. It stands to reason that the solvents that can be used as the mobile phase for liquid chromatography must have special properties. The most important properties of the mobile phase for high performance liquid chromatography are ... [Pg.105]

Recently ultra-performance liquid chromatography (UPLC) has been introduced commercially as a new direction in liquid chromatography. In UPLC columns packed with 1.7-pm, particles are operated at pressures up to lOOMPa. The main advantage is obviously the reduction in analysis time that has been demonstrated for pharmaceutical analysis [16] and metabolomics [17]. [Pg.588]

Ultra-High-Performance or Ultra-High-Pressure Liquid Chromatography... [Pg.198]

UHPLC Ultra high-performance or ultra-high pressure liquid chromatography... [Pg.220]

The penalty for using fine particles is resistance to solvent flow. Until recently, HPLC operated at pressures of 70-4(X) bar to attain flow rates of 0.5-5 mL/min. In 2004, equipment became available to employ 1.5- to 2-p.m-diameter particles at pressures up to 1 000 bar. These instruments provide increased resolution or decreased run time. Chromatography with 1.5- to 2-p,m-diameter particles at high pressure is commonly called UPLC (Ultra-Performance Liquid Chromatography). [Pg.491]

Also, new-generation HPLC instrument which can exceed the pressure limitation of conventional equipment has been developed. This technique is ultra performance liquid chromatography (UPLC), where small particle size columns with 1.7 pm particle size in combination with high flow rates offers increased speed, resolution, and sensitivity [15]. Ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has shown to be well suited for support of PK studies [16-19], Often, there is a need to improve the sensitivity of the assay for the determination of PK parameters, especially for very potent compounds, since lower amount is administrated, and also for compounds with low bioavailability. UPLC-MS/MS has shown decreased ion suppression and superior sensitivity, and has been successfully applied to PK studies for compounds with low bioavailability [20-22]. [Pg.191]

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Ultra pressure liquid chromatography

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