Lipoproteins Liposome

Lipoprotein Metabolism Lipoproteins Liposomes 5-Lipoxygenase Lipoxygenases Lithocholic Acid Local Anaesthetics Locus... 

Jori, G. (1992) Low-density lipoproteins-liposome delivery systems for tumor photosensitizers in vivo, in Henderson, B.W. and Dougherty, TJ. (Eds.), Photodynamic Therapy. Basic Principles and Clinical Applications, New York Marcel Dekker... 

As an example (among many others) for a new development, a formulation of the cationic lipid GS 2888141 and DOPE (Cytofectin ) has become commercially available [426]. This seems to be the only protocol to permit facilitated oligonucleotide delivery by cationic lipids in up to 50% serum content in assay systems [427]. In future - based on knowledge about lipoproteins - liposome formulations may also comprise proteins or other moieties, which are able to undergo recognition of specific cell-surface epitopes. 

Staining Applications Axons bovine brain tissues mitral/tufted cells retinal ganglion cells bacteria cells lipid bilayers lipid monolayers lipid membranes lipoproteins liposomes membranes neurons neural tracers vessel peptides proteins antibodies ... 

Weinstein, J. N. Blumenthal, R. Klausner, R. D. Carboxyfluorescein leakage assay for lipoprotein-liposome interaction. Methods Enzymol. 1986,128, 657-668. 

Probucol, another di-r-butyl phenol, is an anti-atherosclerotic agent that can suppress the oxidation of low-density lipoprotein (LDL) in addition to lowering cholesterol levels. The antioxidant activity of probucol was measured, using EPR, with oxidation of methyl linoleate that was encapsulated in liposomal membranes or dissolved in hexane. Probucol suppressed ffee-radical-mediated oxidation. Its antioxidant activity was 17-fold less than that of tocopherol. This difference was less in liposomes than in hexane solution. Probucol suppressed the oxidation of LDL as efficiently as tocopherol. This work implies that physical factors as well as chemical reactivity are important in determining overall lipid peroxidation inhibition activity (Gotoh et al., 1992). 

The fate of injected liposomes is drastically altered by administration route, dose and size, lipid composition, surface modification, and encapsulated drugs. Liposomes encapsulating drugs are often administered iv, therefore, the stability of liposomes in plasma is important. When liposomes composed of PC with unsaturated fatty acyl chains are incubated in the presence of serum, an efflux of internal solute from the liposomes is observed. This increase in permeability is caused by the transfer of phospholipids to high density lipoprotein (HDL) in serum (55). To reduce the efflux of liposomal contents, cholesterol is added as a liposomal component... 

Heinonen IM, Meyer AS and Frankel EN. 1998. Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation. J Agric Food Chem 46 4107 1112. 

Ramprasad, M.P., Fischer, W., Witztum, J.L., Sambrano, G.R., Quehenberger, O., and Steinberg, D., 1995, The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosiaUn, the mouse homologue of human CD68, Proc. Natl. Acad. Sci. U.S.A. 92 9580-9584. 

Koller-Lucae SM, Schott H, Schwendener RA. Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N -octadecyl-l-P-o-arabino-furanosylcytosine (NOAC) in Daudi lymphoma cells. Br J Cancer 1999 80 1542. 

Lakkaraju A, Rahman YE, Dubinsky JM. Low-density lipoprotein receptor-related protein mediates the endocytosis of anionic liposomes in neurons. J Biol Chem 2002 277(17) 15085-15092. 

In theory, it shonld be possible to alleviate the symptoms of an enzyme dehciency by administering the missing enzyme bnt this is made difficult becanse enzymes do not cross membranes and so fail to enter cells and they also indnce an immnne response. A solution is the nse of liposomes - small lipoprotein vesicles in which enzymes are entrapped so that they fuse with the plasma membrane in vivo and introdnce the enzymes into the cell. The liposome protects the introdnced enzyme from both the host s immnne system and from degradative enzymes. This approach has been used particularly in the treatment for deficiencies of enzymes in the lysosomes. 

Versluis, A.J., PC. Rensen, E.T. Rump, T.J. Van Berkel, and M.K. Bijsterbosch, Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes. Br J Cancer, 1998. 78(12) 1607-14. 

O-antigen of 180 structures of 430 Lipoprotein(s) 58 bacterial 428 Liposomes 392, 392-394 NMR spectra 396 Liquid crystals 392-394 Liquid crystalline phases 392 Lithium salts, in treatment of manic-depressive illness 564 Lithostatine 443 Liverworts 29... 

Both lipoprotein lipase and the less well understood hepatic lipase are related structurally to pancreatic lipase.42,4213 In addition to hydrolysis of the triacylglycerols, the uptake of materials from lipoproteins probably involves shedding of intact phospholipids, perhaps as liposome-like particles 40... 

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