5- lipoxygenase inhibitor

Lipoxygenase AVNTR polymorphism in 100 bp upstream from the ATG start codon is associated with transcription efficiency. Differences in response to 5-lipoxygenase inhibitors and leucotriene receptor antagonists. 

JP04 321 624 (Hisamitsu Pharm. appl. 19.4.1991 J-prior. 19.4.1991). combination with 5-lipoxygenase inhibitors ... 

Hui, P.H., Taylor, I.K., Taylor, G.W., Rubin, P., Kesterton, J., Barnes, N.C. and Barnes, P.J. (1991). Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax 46, 184-189. 

Payne, A.N., Jackson, W.P., Salmon, J.A., Nicholls, A., Yeadon, M. and Garland, L.G. (1991). Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions 34, 189-199. 

Yeadon, M., Eve, D. and Payne, A.N. (1993c). Induction of airway hyperresponsiveness increases the potency of BW B70C, a 5-lipoxygenase inhibitor, to prevent allergic bron-choconstriction in sensitised guinea-pigs. Br. J. Pharmacol. 108, 186P. 

Lipid-lowering agents, 40 (2002) 1 5-Lipoxygenase inhibitors and their antiinflammatory activities, 29 (1992) 1 Literature of medicinal chemistry, 6 (1969) 266... 

K10. Klabunde, R. E., and Calvello, C., Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. Shock 4, 368-372 (1995). 

Fukuishi N, Takada T, Fukuyama Y, Akagi M. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. Phytomedicine 2001 8 460-464. 

Lipoxygenase Inhibitors and their Anti-inflammatory Activities... 

---