Neural tracer

J. Li, H. H. Ha, L. Guo, D. Coomber, Y. T. Chang, Discovery of novel zebraflsh neural tracers by organism-based screening of a rosamine library. Chem. Commun. 2010, 2932-2934. 

Staining Applications Axons bovine brain tissues mitral/tufted cells retinal ganglion cells bacteria cells lipid bilayers lipid monolayers lipid membranes lipoproteins liposomes membranes neurons neural tracers vessel peptides proteins antibodies ... 

Marin, G. Henny, R Letelier, J. C. Sentis, E. Karten, H. Mrosko, B. Mpodozis, J. A simple method to microinject solid neural tracers into deep structures of the brain. J. Neurosci Methods 2001, 106, 121-129. 

A PET scan requires a substance called a tracer. A suitable tracer must accumulate in the target organ, and it must be modified to contain unstable radioactive atoms that emit positrons. Glucose is used for brain imaging, because the brain processes glucose as the fuel for mental and neural activities. A common tracer for PET brain scans is glucose modified to contain radioactive fluorine atoms. Our molecular inset shows a simplified model of this modified glucose molecule. 

Receptors for IGF peptides have also been described in a wide variety of other cells and tissue preparations, of which liver (K3, M13), adipocytes (Zl), chondrocytes (P4) and chondrosarcoma (A9), fibroblasts (A4), pituitary and neural tissues (G6, S7), erythrocytes (P12) and lymphocytes (Rll), Sertoli cells (B31), and arterial smooth muscle (P3) represent a cross-section. In general it appears that the structurally defined (M7) type-I and type-II growth factor receptors fit satisfactorily into two functional classes. The type-I receptor has a high affinity for SM-C/IGF-I, a somewhat lower (but sometimes equal) affinity for IGF-II, and low affinity for insulin (O.I to 1% of that for SM-C/IGF-I). The type-II receptor has a high affinity for IGF-II, low to moderate affinity for SM-C/IGF-I, and does not interact at all with insulin. A type-III receptor for IGF-II has recently been postulated to exist on IM-9 lymphocytes (H2I), but whether this will eventually turn out to be a distinct structural class, or simply the result of interactions of IGF-II tracer with IGF-I, IGF-II and insulin receptors, remains to be established. 

Hoshi, H. O Brien, J. Mills, S. L. A novel fluorescent tracer for visualizing coupled cells in neural circuits... 

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