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Lipids breast milk

Strategies for reducing risk to the infant from drug transferred through breast milk include selection of medications for the mother that would be considered safe for use in the infant choosing medications with shorter half-lives selecting those that are more protein bound, have lower bio-availability, and have lower lipid solubility. [Pg.375]

Dichlorobenzene is classified as an organochlorine compound and, as such, shares many of the biochemical characteristics of this class of chemicals, which includes high lipid solubility. A few studies have noted that 1,4-dichlorobenzene will preferentially distribute to adipose tissues in relatively high amounts, compared to accumulations in the liver and kidneys (Hawkins et al. 1980 Charbonneau et al. 1989b Klos and Dekant 1994). Loss of maternal body fat may mobilize 1,4-dichlorobenzene from fat storage deposits in exposed mothers. This mobilization could result in increased blood levels and/or excretion of 1,4-dichlorobenzene and its metabolites from the mother, as well as redistribution to other fat deposition sites, such as the high fat content found in breast milk. [Pg.104]

Lactation It is not known whether tizanidine is excreted in human milk although, as a lipid-soluble drug, it might be expected to pass into breast milk. [Pg.1289]

B. Lipid-soluble molecules are more likely to be excreted in breast milk because it is primarily a passive diffusion process. A, C, and D are not correct because they are opposite of the typical characteristics of drugs excreted into breast milk. [Pg.47]

Benzodiazepines are lipid soluble and are found in breast milk. They are metabolized in the liver and excreted as glucuro-nide metabolites at different rates. For example, the half-life of triazolam is 2 to 5 hours, while that of diazepam varies between... [Pg.79]

Concentrations (in ng/g Lipid Weight) of Several PBDEs in Human Breast Milk Samples... [Pg.16]

Excretion into breast milk can be a very important route for certain types of foreign compounds, especially lipid-soluble substances, because of the high lipid content in milk. Clearly, newborn animals will be specifically at risk from toxic compounds excreted into milk. For example, nursing mothers exposed to DDT secrete it into their milk, and the infant may receive a greater dose, on a body-weight basis, than the mother. Also, because the pH of milk (6.5) is lower than the plasma, basic compounds may be concentrated in the fluid. [Pg.71]

Lampe, M.F., et al. 1998. Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk. Antimicrob Agents Chemother 42 1239. [Pg.435]

A review of the absorption, distribution and metabolism of PBBs in animals—mainly cattle and rodents—is already extant and will not be covered here (See DiCarlo et al, ref. 155). Suffice it to say that excretion rates of PBBs are exceedingly low, hence their biological half-lives long. Continued exposure leads to the build-up of PBBs in body fats. A major excretion route is via the lipid fraction of breast milk. [Pg.358]

Evidence is similar for humans but limited, and includes male sterility, spontaneous abortions in human females, premature human fetuses, severe neurologic and CNS effects, blood dyscrasias, hepatotoxicity, accumulation of organohalogen pesticides in human lipid tissue—and, perhaps even more important, their presence in human breast milk, whence they can continue to exert influences on growth, development and hormonal, CNS and enzyme systems. Aldrin, dieldrin, chlordane, chlordecone (Kepone), heptachlor epoxide, hexachlorobenzene (HCB) and Mirex are all excreted via breast milk in the human female. This is also true for the related PCBs and PBBs that resist biodecomposition and maintain persistent residence in mammalian tissues. For them, excretion via breast milk may constitute the main—if not sole—elimination route. [Pg.407]

Bi and Xu (2000) reported the residue levels of PBDEs in human serum and breast milk samples from southern China. The concentrations of seven congeners ranged from 1.5 to 17 ng g 1 lipid. The levels were within the range reported in European samples but lower than that reported in North American samples. [Pg.226]

Apart from classical organochlorines, not much literature is available on the occurrence of other PTS compounds like butyltins, polybromin-ated diphenyl ethers, etc. in Indian human breast milk. Indian Council of Medical Research (ICMR) in their news bulletin of the year 2004 has indicated that they could detect PCDDs and PCDFs in the human milk samples collected from Ahmedabad, Vadodara and Surat cities (http //icmr.nic.in). They have found that the TEQs of dioxins and related compounds in their samples ranged from about 2 to 16 pg g 1 lipid weight of human milk. [Pg.469]

Me Tri and Tu Liem, Hanoi 2000 Breast milk, multiparas women near municipal dumping sites ng g-1 lipid 1700 46 1.4 3.5 72 Minh et al. (2004) only CHLs sum of oxychlordane, trans- nonachlor, and... [Pg.538]

Tan Than village, suburb Hochiminh City 1985-1987 Breast milk, rural area ng g 1 lipid 2 10500... [Pg.539]


See other pages where Lipids breast milk is mentioned: [Pg.236]    [Pg.375]    [Pg.148]    [Pg.21]    [Pg.104]    [Pg.149]    [Pg.53]    [Pg.68]    [Pg.518]    [Pg.24]    [Pg.899]    [Pg.198]    [Pg.213]    [Pg.241]    [Pg.244]    [Pg.248]    [Pg.364]    [Pg.371]    [Pg.372]    [Pg.376]    [Pg.300]    [Pg.418]    [Pg.13]    [Pg.937]    [Pg.395]    [Pg.91]    [Pg.226]    [Pg.347]    [Pg.469]    [Pg.470]    [Pg.537]    [Pg.538]    [Pg.538]    [Pg.538]   
See also in sourсe #XX -- [ Pg.35 , Pg.62 , Pg.63 ]




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Breast lipids

Breast milk

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