Level total, determination

Two methods were used to determine the purity of the final material. The ash content was obtained by calculation of a weight loss of 1 g size graphite sample, after its exposure to 900°C for 4 hours (Superior Graphite AIMS procedure FBQ0001). This test gives a good idea of the total amount of impurities. The nature of impurities and their specific concentrations as measured in ppm or ppb levels, was determined with an ICP inductively coupled plasma spectrometer (Model Jobin Yvon Ultima POXX/681,... 

Hirose and Sugimura [89] investigated the speciation of plutonium in seawater using adsorption of plutonium (IV)-xylenol orange and plutonium-arsenazo (III) complexes on the macroreticular synthetic resin XAD-2. Xylenol orange was selective for plutonium (IV) and arsenazo (III) for total plutonium. Plutonium levels were determined by a-ray spectrometry. 

The assumption can be made that degradation is dependent on total radiation dose but is independent of dose rate (see Section 6.13). However, acceleration levels can be very high and this is a prime reason why, in practice, it is often found that the effect of a given dose decreases with increased dose rate. The limiting factor is the rate of oxygen diffusion. Recommended practice is to test at two or more dose rate levels to determine the magnitude of this effect. 

Adjunctive therapy - Divalproex sodium or valproic acid may be added to the patient s regimen at a dosage of 10 to 15 mg/kg/day. The dosage may be increased by 5 to 10 mg/kg/wk to achieve optimal clinical response. Ordinarily, optimal clinical response is achieved at daily doses less than 60 mg/kg/day. If satisfactory clinical response has not been achieved, measure plasma levels to determine whether they are in the usually accepted therapeutic range (50 to 100 mcg/mL). If the total daily dose exceeds 250 mg, administer in divided doses. 

For incorporation of crown ethers and cryptates into the RTV encapsulant system as sodium and potassium ion scavengers, the total ionic contaminants must first precisely be determined. Atomic absorption is used to measure these ions in commercial silicone RTVs and silicone fluids. Values of "10 ppm for sodium and potassium were obtained in the best samples. Chloride level was determined by potentiometric titration of the silicone with AgN03. A quantity of ion trap (either crown ethers or cryptates) was then added to the RTV silicone encapsulant, and its molar concentration was equal to the combined sodium and potassium contaminant levels. 

Two conditions must be met to justify comparisons between f values determined by different electrokinetic measurements (a) the effects of relaxation and surface conductivity must be either negligible or taken into account and (b) the surface of shear must divide comparable double layers in all cases being compared. This second limitation is really no problem when electroosmosis and streaming potential are compared since, in principle, the same capillary can be used for both experiments. However, obtaining a capillary and a migrating particle wiih identical surfaces may not be as readily accomplished. One means by which particles and capillaries may be compared is to coat both with a layer of adsorbed protein. It is an experimental fact that this procedure levels off differences between substrates The surface characteristics of each are totally determined by the adsorbed protein. This technique also permits the use of microelectrophoresis for proteins since adsorbed and dissolved proteins have been shown to have nearly identical mobilities. 

Figure 8.5 Pomegranate by-product (PBP) consumption by E° mice attenuates atherosclerotic lesion development, in association with reduction in macrophage oxidative stress and Ox-LDL uptake. E° mice consumed PBP (17 or 51.5 mg gallic acid equivalents/kilogram/day) for 3 months. Control mice received only water (placebo). At the end of the study, the mice aortas as well as the mice peritoneal macrophages were harvested. (A) Atherosclerotic lesion size determination. (B) Total macrophage peroxide levels were determined by the DCFH-DH assay. (C) For determination of macrophage paraoxonase 2 (PON2) lactonase activity, cells (2 x 10e) were incubated with 1 mmol/L dihydrocoumarin in Tris buffer, and the hydrolysis rate was determined after 10 min of incubation at 25°C. (D) The extent of Ox-LDL (25 pg of protein/ milliliter, labeled with FITC) uptake by the mice macrophages (1 x 10e) was determined by flow cytometry. Results are expressed as mean S.D. of three different determinations. = p < 0.01 versus placebo.

Determination of Vitamin E and Se Levels in Tissues. Vitamin E levels (at total tocopherol) were determined by the spectro-fluorometric method of Taylor, et al. (25). Selenium levels were determined spectrofluorometrically as described by Whetter and Ullrey (24). 

Regular blood tests are required to check for cytopenia, especially neutropenia. The Summary of Product Characteristics for hydroxycarbamide states The complete status of the blood, including bone marrow examination, if indicated, as well as kidney function and liver function should be determined prior to, and repeatedly during, treatment. The determination of haemoglobin level, total leukocyte counts, and platelet counts should be performed at least once a week throughout the course of hydroxycarbamide therapy. If white blood cell count falls below 2.5 x 109/L or platelet count to <100 x 109/L, therapy should be interrupted. Counts should be rechecked after 3 days and treatment resumed when they rise significantly towards normal. 

As was previously noted (Section 6.2), the total and prostatic serum acid phosphatase levels were determined by the method of Fishman and Lerner (FI) in a series of 365 males attending a cancer-prevention clinic (D6). The values for the total acid phosphatase activities in the 315 patients of this group who had no prostatic enlargement have already been described (Table 6). In groups of the size under consideration, values within 2.5 standard deviations of the mean can be considered as normal ... 

A total of five animals of one sex will normally be used for each concentration level investigated, in addition to the single animal used in the sighting study. The time interval between exposures at each level is determined by the onset, duration, and severity of toxic signs. Treatment of animals at the next concentration should be delayed (initially 3-4 days is recommended) until there is confidence in the survival of the previously tested animals. 

Formaldehyde levels are determined by the chromotropic acid method using midget impingers to collect samples. Total oxidant is measured periodically with a coulometric ozone meter (Mast Development Co.). The response of the meter to ozone, nitrogen dioxide, and peroxyacyl nitrate is determined by calibration experiments, and the oxidant level is expressed as ozone, with the contribution of nitrogen dioxide removed. 

In the present study, three groups of six cattle (a total of eighteen) were administered the Captec device intra-ruminally via a fistula. Drug release rates were determined by HPLC assay of ABZ and its major metabolites in plasma as well as by physical measurement of the plunger movement. ABZ marker residue levels were determined using the established regulatory procedure in total liver, an ethyl acetate extractable fraction as well as the remaining intractable (bound) residue on each of three cattle at 0- and 5-Day withdrawal. 

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