Leg cramps

Chloroquine (Aralen) is also used in die treatment of extraintestinal amebiasis (see section on Amebicides). Doxycycline is also used to treat infections caused by Neisseria gonorrhoeae, Treponema pallidum, Listeria monocytogenes, Clostridium, and Bacillus anthracis when penicillin is contraindicated. Quinine also may be used for die prevention and treatment of nocturnal leg cramps. 

Anorexia, nausea, vomiting, mental depression, confusion, delayed or impaired thought processes, drowsiness, abdominal distention, decreased bowel sounds, paralytic ileus, muscle weakness or fatigue, flaccid paralysis, absent or diminished deep tendon reflexes, weak irregular pulse, paresthesias, leg cramps, ECG changes Hyperkalemia... 

Adverse effects of raloxifene include hot flashes, leg cramps, and increased risk of venous thromboembolism. Hot flashes are very common and may be intolerable in postmenopausal women who are already predisposed to experiencing them. A more serious adverse effect is a threefold increased risk of venous thromboembolism that was found in patients treated in the MORE trial.30 A previous history of venous thromboembolism is a contraindication to therapy. 

Hot flushes, leg cramps, venous thromboembolism, peripheral edema, rare cataracts and gallbladder disease black box warning for fatal stroke... 

Pain at injection site, nausea, dizziness, leg cramps, rare increase in uric acid, slightly increased calcium... 

Common Cramps, nausea and vomiting, Pain and brown staining Leg cramps, hypoten-... 

Body as a whole (general disorders) Hot flashes Leg cramps... 

On significant inhalation of metallic mercury vapors, some people (primarily children) exhibit a syndrome known as acrodynia, or pink disease. Symptoms include severe leg cramps, irritability, erythema, and subsequent peeling of the hands, nose, and soles of the feet. ... 

Adverse events whether or not related to iron sucrose administration reported by more than 5% of treated patients are as follows hypotension (36%) cramps/leg cramps (23%) nausea, headache, vomiting, and diarrhea. 

Adults - Adverse reactions experienced by at least 5% of patients receiving sodium ferric gluconate complex include the following abdominal pain, abnormal erythrocytes, asthenia, chest pain, cramps, diarrhea, dizziness, dyspnea, fatigue, fever, generalized edema, headache, hyperkalemia, hypertension, hypotension, injection-site reaction, leg cramps, nausea, pain, paresthesias, pruritus, syncope, tachycardia, upper respiratory tract infection, vomiting. 

Musculoskeletal - Back pain, musculoskeletal pain (5% or more) arthralgia, leg cramps, myalgia (2% to less than 5%). 

WARNING Long-acting p2-agonists may t risk of asthma-related death Uses COPD maint Action LA p2-agonist, relaxes airway smooth muscles Dose 15 meg neb bid, 30 meg/d max Caution [C, ] w/ CV Dz, X Contra Not for acute asthma component hyp sensitivity peds w/ phenothiazines Disp Meg neb SE Chest/back pain, D, sinusitis, leg cramps, dyspnea, rash, flu-synd, t BP, arrhythmias, heart block J-K EMS Monitor ECG for arrhythmias, heart block, and hypokalemia (flattened T waves) t risk of acute asthma attack, treat w/ shortacting p-agonist OD May cause CP, palpitations, muscle tremors and cramps, and syncope symptomatic and supportive... 

Ca, leg cramps EMS May cause cardiac conduction abnormalities d/t T monitor ECG not used to prevent osteoporosis osteosarcoma has been rqwrted in animals OD May cause NA, HA, and h5 percalcemia and associated cardiac conduction problems s5rmptomatic and supportive... 

Adverse reactions associated with their administration include hypertension, headache, and possible seizures. Nausea, vomiting, chest pains, difficulties in breathing, and leg cramps also have been reported. These alkaloids should not be used in cases of threatened spontaneous abortion or in patients with known allergies to the drugs. Contraindications generally include angina pectoris, myocardial infarction, pregnancy, and a history of a cerebrovascular accident, transient ischemic attack, or hypertension. 

Leg cramps, paresthesia, rash, vomiting Serious Reactions... 

Acne, leg cramps, gingival hyperplasia (marked by red, bleeding, and tender gums), paresthesia, diarrhea, nausea, vomiting, headache Rare (less than 1 %)... 

Abdominal discomfort, diarrhea, leg cramps, impaired vision Serious Reactions... 

Interferon alfa-26 Confusion, leg cramps, back pain, gingivitis, flushing, tremor, nervousness, eye pain... 

Nausea, pruritus, edema, hypotension, nervousness, vertigo, depression, dizziness, headache, malaise, painful blistering, burning, rash, urticaria, loss of muscle coordination, leg cramps... 

Nocturnal leg cramps PO 260-300 mg at bedtime as needed. Treatment of malaria PO 260-650 mg 3 times a day for 6-12 days. Dosage in renal impairment ... 

Weight gain, nausea, myalgia, pharyngitis, cough, dyspepsia, leg cramps, rash, depression Rare (4%-3%)... 

Notify the physician if leg cramps, weakness, weight gain, or vaginal bleeding, itching, or discharge occurs... 

Leg cramps, nausea, dizziness, headache, orthostatic hypotension, increased heart rate... 

Fatigue, nausea, diarrhea, abdominal pain, leg cramps, headache Rare... 

Adverse effects include flushing, urticaria, hypotension, shock, tachypnoea, hypoxaemia, tachycardia, cardiac arrhythmias, convulsions, erythema, swelling, GIT disturbances, dysuria, fever, allergic skin rashes. Leg cramps on long term therapy and reversible ocular and auditory disturbances have also been reported. 

Quinine Quinine, molecular formula C20H24N2O2, is a white crystalline quinoline alkaloid, isolated from Cinchona hark Cinchona succirubra), and is well known as an antimalarial drug. Quinine is extremely bitter, and also possesses antipyretic, analgesic and anti-inflammatory properties. While quinine is stiU the drug of choice for the treatment of Falciparum malaria, it can be also used to treat nocturnal leg cramps and arthritis. Quinine is an extremely basic compound, and is available in its salt forms, e.g. sulphate, hydrochloride and gluconate. 

Pregnancy can be prevented following coitus by the administration of estrogens alone, progestin alone, or in combination ("morning after contraception). When treatment is begun within 72 hours, it is effective 99% of the time. Some effective schedules are shown in Table 40-4. The hormones are often administered with antiemetics, since 40% of the patients have nausea or vomiting. Other adverse effects include headache, dizziness, breast tenderness, and abdominal and leg cramps. 

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