Lacks, Henrietta

There are now available a number of lines of cells, mainly originating from malignant tissue, which can be serially subcultured apparently indefinitely. These established cell lines are particularly convenient as they eliminate the requirement for fresh animal tissue for such sets or series of cultures. An example of these continuous cell lines are the famous HeLa cells, which were originally isolated from a cervical carcinoma of a woman called Henrietta Lacks, long since dead but whose cells have been used in laboratories all over the world to grow viruses. 

In the laboratory the immortal cell lines are those derived from cancer. The most famous is the HeLa cancer cells that many of us use as one of the cell lines tested against various anticancer agents. The name HeLa cells is derived from Henrietta Lacks, a black woman, who died from cervical cancer. The cells are so strong that they invade other cell lines, both healthy and other cancer cell lines, giving contaminated or mutated cell lines. HeLa cells have good telomerase levels. If antisense RNA is added to HeLa cells so that the RNA contains the opposite message to the ordinary RNA in the telomerase, the effect is that the telomerase is blocked and the HeLa cells are no longer immortal and die after about 25 replications. 

Cell line (Henrietta Lacks, immortal cell line)... 

Henrietta Lacks (HeLa cells immortal cell line derived from H.L. s cervical cancer cells) heteronuclear correlation (NMR) hydrophobin... 

It has been demonstrated very recently that SILAC is applicable to multiplex experiments in order to measure dynamics of protein abundances in cells in response to stimuli such as growth factors or drugs (Molina et al, 2005). Henrietta Lacks (HeLa) cells were grown in normal medium or in media lacking normal... 

A HeLa cell (also Hela or hela cell) is an immortal cell line used in medical research. The cell Une was derived from cervical cancer cells taken from Henrietta Lacks, who died from her cancer on October 4, 1951. 

Furthermore, the induction of apoptosis in HeLa (a cell type in an immortal cell line used in scientific research it is the oldest and most commonly used human cell line and was derived from cervical cancer cells from Henrietta Lacks, a patient who eventually died of cancer) and MiaPaCa cells (human pancreatic carcinoma cells) was evident within 2 h, with the progression of cells through early and into late apoptosis. The levels of apoptosis occurring suggested that this was the dominant mode of cell death and was evident by the levels of late apoptosis/necrosis at 24 h. Mitochondria are involved in both apoptotic and necrotic death processes, influenced by the level of adenosine triphosphate and the activation of caspases [78]. 

Background The assanbly of the ribosomal complex depends on the presence of proteins called enkaryotic initiation factors (elEs). In mammals the largest of these is eIF3, an -800 kDa noncovalent complex comprising of 13 stoichiometric nonidentical subunits ranging in mass from 25 to 167 kDa. This paper describes the isolation and characterization of human eIE3 obtained from HeLa cells (an inunortal cell line derived from cervical cancer cells from Henrietta Lacks in 1951). 

HeLa cells Cells from Henrietta Lacks... 

This immortal cell line is derived from a cervical cancer (Henrietta Lacks, deceased October 1951). 

Derived from the cervical carcinoma of Henrietta Lacks (a pseudonym). These cells are used for virus culture and screening antitumor dmgs. 

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