Killer cells, mononuclear

Natural-killer cell enhancement. Polysaccharide fraction of the rhizome, administered intragastrically to female mice at a dose of 1 g/kg, produced weak activity vs mononuclear cell incubated with YAG-1 cells ° 5... 

Non-specific cellular immunity All other immune cell types such as granulocytes, various cells of the mononuclear phagocytosis system (macrophages/ monocytes, dendritic cells) or natural killer cells form part of the (less specialized) innate immunity. 

BsAb 2B1 recognizes both HER2 and CD 16, the low-affinity type III Fc receptor (FcyRIII) expressed by mononuclear phagocytes and natural killer cells. In a phase I clinical study, 2B1 was shown to induce cytokine release, and several minor antitumor responses were observed (255). 

Bryostatin 1 binds to the regulatory domain of protein kinase C short-term exposure promotes activation of protein kinase C, whereas prolonged exposure promotes significant down-regulation (4). In preclinical and phase I clinical studies it had promising antitumor and immuno-modulating effects. It amplifies expansion of myeloid and erythroid progenitor cells stimulated by the cytokines GM-CSF, M-CSF, and IL-3. Similarly, it induces the production of peripheral blood mononuclear cells with enhanced lymphokine-activated killer cell activity and proliferation in the presence of IL-2 (5). 

D Andrea, A., Rengaraju, M., Valiante, N.M., Chehimi, J., Kubin, M., Aste, M., Chan, S. H., Kobayashi, M., Young, D., Nickbaig, E. etal. (1992). Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176, 1387-1398. 

Some phenothiazines, the so-called half-mustard type, stimulated T-cell blast formation, presented a natural killer cell activity, via possibly the activation of monocytes and macrophages, and an antibody-dependent cellular cytotoxicity of human peripheral blood mononuclear cells, and also showed cytotoxicity against several human cancer cell lines. These phenothiazines also might induce an in vivo antimicrobial activity by possibly their host-mediated immuno-potentiation [146]. Phenothiazines did not demonstrate any apparent mutagenic activity, but they were rather antimutagenic. These data suggest the possible applicability of half-mustard type phenothiazines and benzo[a]phenothiazines to cancer chemotherapy. 

Note DTH, delayed hypersensitivity skin response NC, no change NK, natural killer cell PBMC, peripheral blood mononuclear cells P, proliferation M, men W, women mean pertains to mean age. 

Lysis of various target cells coated with antibody by Fc receptor-bearing killer cells, including large granular lymphocytes ( - natural killer cells), neutrophils, eosinophils, and mononuclear phagocytes. 

Adoptive therapy attempts to overcome blocks to the efferent arm of the immune system by harvesting immune cells from the patient, manipulating them to activate them or otherwise increase their effectiveness and then re-infusing them to target the tumor. Classically, the cell types used have included peripheral blood mononuclear cells (PBMC), lymphokine-activated killer cells (LAK), tumor infiltrating lymphocytes (TIL), and cytotoxic lymphocytes (CTL). 

D Andrea A, Rengaraju M, Valiante NM, et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992 176 1387-1398. 

Adult bone marrow-derived stem cells are presently the cell types most widely utilized in cardiac stem cell therapy. A heterogeneous subset, termed autologous bone marrow-derived mononuclear cells (ABMMNCs), is composed of small amounts of stromal or MSCs, HPCs, EPCs, and more committed cell lineages, such as natural killer lymphocytes, T lymphocytes, B lymphocytes, and others [2]. 

Natural killer (NK) cells are mononuclear cells able to lyse tumor cells without prior sensitization to specific antigens [84], When NK cells... 

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