Kidney pathology

Anemia, elevation in erythrocyte porphyrin, kidney pathology residues (mg/kg fresh weight) of 603 in kidney, 501 in bone, 8 in liver, 2 in brain, 4.4 in blood, 0.8 in sciatic nerve, and 0.1 in crop... 

No data were found on the effects of silver compounds on avian or mammalian wildlife. All controlled studies with silver were with domestic poultry, livestock, or small laboratory mammals. Signs of chronic silver ion intoxication in tested birds and mammals included cardiac enlargement, vascular hypertension, hepatic necrosis, anemia, lowered immunological activity, altered membrane permeability, kidney pathology, enzyme inhibition, growth retardation, and a shortened life span (Smith and Carson 1977 Freeman 1979 Fowler and Nordberg 1986 USPHS 1990). 

Renal Effects. Diffuse degenerative changes were observed in the kidneys of rabbits and mice that died following exposure to 0.36 ppm (15 mg/m3) of endrin (Treon et al. 1955). No further details of the kidney pathology were provided. No studies were located regarding renal effects in humans after inhalation exposure to endrin, endrin aldehyde, or endrin ketone. 

Increasing blood lead levels from 3rd month, 20 according to dose kidney pathology. Effects more severe in those on low calcium diets... 

Pulmonary irritation, headache, nausea, fatigue, muscular weakness, liver and kidney pathology (3)... 

By contrast, organotin compounds produce similar health effects in humans and animals after acute and intermediate inhalation exposure. Deaths in workers exposed to methyltins were preceded by respiratory depression and neurobehavioral changes. Autopsies revealed liver and kidney pathology. Irritation of the upper respiratory tract and skin and eye irritation have been seen in humans. Generally speaking, the animal data confirm the human effects after inhalation exposure to the organotins. 

Hard, G. C., Howard, P. C., Kovatch, R. M., and Bucci, T. J. (2001). Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor. Toxicol. Pathol. 29(3), 379-386. 

The highest experimental exposure levels that did not cause decreased hematocrit, kidney pathology, behavioral changes, or lethality (effects observed at higher exposures were above the definition for AEGL-2) have been used as the basis for determining AEGL-2 values. 

Dische FE, Neuberger J, Keating J, Parsons V, Caine RY, Williams R. Kidney pathology in liver allograft recipients after long-term treatment with cyclosporin A. Lab Invest 1988 58 395-402. 

Lamb EJ, O Riordan SE, Delaney MR Ageing and the kidney pathology, assessment and management. Chn Chim Acta 2003 334 25-40. 

Storkel S. Epithelial tumors of the kidney. Pathological subtyping and cytogenetic correlation. Urologe A. 1999 38 425. 

There was no kidney pathology in rats or guinea pigs exposed to RDX, but degeneration of the kidneys was found in rabbits exposed to unspecified levels of RDX for an intermediate period (Sunderman 1944). This study is limited in that no controls were used, and details of the study were not specified. 

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