Isopropyl cresol

SYNS P-CYMEN-3-OL 3-p-CYMENOL 3-HYDRO-XY-p-CYMENE 3-HYDROXY-1-METHYL-4-ISOPROP-YLBENZENE ISOPROPYL CRESOL 6-ISOPROPYL-m-CRESOL 2-ISOPROPYL-5-METHYLPHENOL 1-METHYL-3-HYDROXY-4-ISOPROPYLBENZENE 5-METHYL-2-ISOPROPYL-1-PHENOL 5-METHYL-2-(l-METHYLETHYL)PHENOL THYME CAMPHOR THYMIC ACID m-THYMOL... 

Addo trimico 3-p-cymenol p-cymen-3-ol Flavinol 3-hydroxy-p-cymene 3-hydroxy-l-methyl-4-isopropylbenzene Intrasol isopropyl cresol isopropyl-w-cresol 6-isopropyl-m-cresol isopropyl metacresol 2-isopropyl-5-methylphenol 1-methyl-3-hydroxy-4-isopropylbenzene 5-methyl-2-isopropyl-phenol 5-methyl-2-(l-methylethyl) phenol Medophyll thyme camphor thymic acid m-thymol timol. 

AI3-00708 Caswell No. 856A CCRIS 7299 Cymo-phenol, a- EINECS 201-944-8 ERA Pesticide Chemical Code 080402 FEMA Number 3066 HSDB 866 Isopropyl cresol NSC 11215 Thyme camphor Thymic acid Thymol m-Thymol Thymol (natural). An antibacterial and antifungal agent used in perfumery, microscopy, preservative, antioxidant, flavoring, as a laboratory reagent, in the manufacture of menthol. Used in the prevention of mold and mildew, in flavoring and perfumery, as a preservative and antioxidant and a topical antiseptic. Crystalline solid mp = 51,5° bp = 232.5" dl ... 

CAS 3228-02-2 EINECS/ELINCS 221-761-7 Synonyms 4-lsopropyl-m-cresol Isopropyl cresols (INCI) 4-lsopropyl-3-methylphenol 3-Methyl-4-isopropylphenol 3-Methyl-4-(1-methylethyl) phenol p-Thymol... 

Synonyms 3-p-Cymenol p-Cymen-3-ol 3-Hydroxy-p-cymene 3-Hydroxy-1 -methyl-4-isopropy I benzene Isopropyl cresol 6-lsopropyl-m-cresol Isopropyl-m-cresol Isopropyl metacresol 2-lsopropyl-5-methylphenol 1-Methyl-3-hydroxy-4-isopropylbenzene... 

In the 1960—1980 period, the use of more economical synthetic isopropyl- and /-butylphenols as alternatives to cresols was developed (98,99). Commercial triaryl phosphates such as FMC s Kronitex 100 and Ak2o s Phosflex 31P and 41B are based on partially isopropylated or /-butylated phenol. The relative volatihties and oxidative stabiUties of these phosphates have been compared the /-butylphenyl phosphates are the most oxidatively stable of the alkylphenyl phosphates (100). 

Triaryl phosphates are produced by reaction of phosphoms oxychloride with phenoHc compounds at 100—200°C with magnesium or aluminum chloride catalyst. Past use of cresols and xylenols from coal tar or petroleum is replaced for lower toxicity and cost by synthetic phenoHcs, primarily isopropyl phenol, /-butyl phenol, and phenol itself A range of viscosities is achieved by selection and proportioning of the phenols and their isomers used for the starting material. 

PMMA is not affected by most inorganic solutions, mineral oils, animal oils, low concentrations of alcohols paraffins, olefins, amines, alkyl monohahdes and ahphatic hydrocarbons and higher esters, ie, >10 carbon atoms. However, PMMA is attacked by lower esters, eg, ethyl acetate, isopropyl acetate aromatic hydrocarbons, eg, benzene, toluene, xylene phenols, eg, cresol, carboHc acid aryl hahdes, eg, chlorobenzene, bromobenzene ahphatic acids, eg, butyric acid, acetic acid alkyl polyhaHdes, eg, ethylene dichloride, methylene chloride high concentrations of alcohols, eg, methanol, ethanol 2-propanol and high concentrations of alkahes and oxidizing agents. 

A)-Menthol can also be made synthetically by hydrogenation of thymol [89-83-8], which can be produced by isopropylation of y -cresol with propylene (143,144). 

Thymol, Cj Hj O, is the principal constituent of the oils of thyme and ajotvan seeds. It is isopropyl-mefa-cresol of the constitution—... 

Carvacrol is isopropyl-orfAo-cresol, of the following constitution —... 

The FTIR spectra of the gas mixture evolved in thermal decomposition of Bisphenol AF poly(formal) (7) at various temperatures suggest the existence of benzene rings, C—O—C bonds, and C=C bonds. In a pyrogram of pyrolysis gas chromatography (Py-GC) of Bisphenol A (3), a-methylstyrene, phenol, p-cresol, 4-hydroxy-amethylstyrene, and isopropyl phenol are observed as major peak products. The cleavage reactions shown in Scheme (5) is suggested for the formation of phenol and 4-hydroxy-a-methylstyrene from Bisphenol A (3). 

The novolac sample, which was provided by Kodak, was synthesized from pure meta-cresol and formaldehyde. It has a weight average molecular weight of 13,000 and a very broad polydispersity of 8.5. The polymer was purified by two precipitations from tetrahydrofuran into hexane. The PAC was a naphthoquinone-1,2-(diazide-2-)-5-sulfonyl ester provided by Fairmount Chemical (Positive Sensitizer 1010). A hydroxyl substituted benzophenone is attached to the sulfonyl ester. The spreading solvent was isopropyl acetate, which was obtained from Aldrich Chemicals and used as received. 

The synthetic process starts with the isopropylation of m-cresol to yield thymol. After catalytic hydrogenation a mixture of stereoisomers is obtained from which (+)-menthol is isolated. The process requires much separation and recycling work. In contrast, the semi-synthetic process of Takasago (Scheme 5.5) leads essentially to stereopure (—)-menthol [19]. 

Thymol (isopropyl-m-cresol) is a volatile, phenolic monoterpene produced by several plants including thyme (Thymus vulgaris L.) (Baerheim Svendsen and Scheffer, 1985). Thymol has well-known antiseptic, antifungal, and anthelminthic properties (Wilson et al., 1977) and is also used for food and fragrance applications (Bauer et al., 1990). 

Some branched alkyl groups, especially the isopropyl group, can readily be replaced by a nitro group, even when they are attached to an aromatic ring. For example, under certain nitration conditions thymol ethers can yield the corresponding trinitro-m-cresol ethers (Giua [198]). Similarly, the nitration of p- cymene may lead to dinitrotoluene (Alfthan [199]) ... 

SYNS 2-p-CYMENOL FEMANo. 2245 2-HYDROXY-p-CYMENE ISOPROPYL-o-CRESOL 5-ISOPROPYL-2-METHYLPHENOL ISOTHYMOL 2-METHYL-5-ISOPROPYLPHENOL o-THYMOL... 

Thymol is obtained from the volatile oil of thyme Thymus vulgaris Linne (Fam Labiatae)) by fractional distillation followed by extraction and recrystallization. Thyme oil yields about 20-30% thymol. Thymol may also be produced synthetically from p-cymene, menthone, or piperitone, or by the interaction of m-cresol with isopropyl chloride. 

The reaction temperature increases with increasing extent of conversion, the hydrochloride formed escaping as a gas. The excess phenol is distilled off when the reaction is complete. The phosphate esters can be purified by distillation. o-Cresol may not be used in the manufacture of cresyl phosphate on ecological grounds. Isopropyl-phenyl phosphate can, however, be produced using phenol mixtures, which are obtained by the alkylation of phenol with propene. 

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