Thymol derivatives

The action of 29 and 30 on PDEl was also assessed to check the relationship between phytotoxicity and CaM inhibition. The results indicated that both thymol derivatives inhibited activation of PDEl in the presence of CaM with IC50 values of 4.4 xM and 4.2 xM, respectively, while chlor-promazine had an IC50 of 6.8 xM. 

Passreiter CM, Matthiesen U, Willuhn G (1998) 10-Acetoxy-9-chloro-8,9-dehydrothymol and Further Thymol Derivatives from Arnica sachalinensis. Phytochemistry 49 111... 

Further thymol derivatives have been isolated from plant sources 49.3% of the oil from Eupatorium triplinerve consists of thymohydroquinone dimethyl ether (166), ° and esters of 1-hydroxythymol methyl ether (167) and 1-hydroxy-... 

Thymol Derivatives.-—Occurrence. Several new thymol derivatives have been obtained from a variety of plant species 870-871 isolation of (263) from roots of a Marshallia sp. was claimed to have chemotaxonomic significence.872 Isothymol (m-menthane skeleton) and its esters occur naturally 873-874 a phenolic ether... 

The naturally occurring thymol derivative 660 (R = COiPr, = Me) has been synthesized by Sanghvi and Rao, using base reaction with the functionalized coumarin 661 (see Vol. 4, p. 522, Ref. 471), to obtain the diol 660 (R = R = H) and then functionalizing the latter. A more complex synthetic goal (not yet achieved) would be the synthesis of areolal (662) reported to occur as the racemate in roots of Piptotrix areolare (Compositae). ... 

Phenols e.g. -alkylresorcinol homologues [1] thymol derivatives [2] hydoxyanthraquinones [3] ratanhia ohenols [41 ... 

Bohlmann et al. have isolated many new thymol derivatives from a number of different species." Doubts over the presence of a y-terpinene monoepoxide reported earlier (Vol. 5, p. 22) in Origanum heracleoticum, and of its synthesis from y-terpinene by peracid epoxidation, have been confirmed. ... 

Liang H, Bao F, Dong X, Tan R, Zhang C, Lu Q, Cheng Y. Antibacterial thymol derivatives isolated from Centipeda minima. Molecules 12(8), 1606-1613, 2007. 

An increase in thymol derivatives production was observed in roots of Inula ensifolia plants inoculated with G. intraradices and Glomus clarum the highest concentration of all the analyzed compounds was found in roots colonized by G. clarum [160]. Enhanced concentrations of anthraquinone derivatives (hypericin and pseudohypericin) were reported in H. perforatum shoots after inoculation with G. intraradices and with a mixed AM fungal inoculum [161]. 

Zubek S, Stojakowska A, Anielska T, Timiau K (2010) Arbuscular myconhizal fungi alto thymol derivative contents of Inula ensifolia L. Mycorrhiza 20 497-504... 

Anthonsen T, Kjosen B 1971 New thymol derivatives from Inula salicina L. Acta Chem Scand 25 390-392... 

Bohlmann, F., C. Zdero, R.M. King, and H. Robinson Naturally Occurring Terpene Derivatives. Part 469. Thymol Derivatives from Porophyllum riedelii. Phytochemistry 22, 1035 (1983). 

Bohlmann, F., and C. Zdero Neue norkauren- und thymol derivate aus Athrixia-diVitn. Phytochem. 16, 1773 (1977). 

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