Tri-o-cresyl-phosphate

Major components Chemical formula Chemical structure Identification numbers Tri-o-cresyl phosphate C2iH2i04P (RO) (RO) (RO) P=0 Predominantly saturated hydrocarbons predominantly in the range C15 through C30 Hydrocarbons predominantly in the range C11 through C20... 

Somkuti SG, Lapadula DM, Chapin RE, et al. 1987a. Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats. Toxicol Appl Pharmacol 89 49-63. 

Suwita E, Abou-Donia MB. 1990. Pharmacokinetics and metabolism of a single subneurotoxic oral dose of tri-o-cresyl phosphate in hens. Arch Toxicol 64 237-241. 

Tri-o-cresyl phosphate, t452 Tricyclene, t400a Tricyclo[3.3.1.13=7]decane, a65... 

S. G. Somkuti, M. B. Abou-Donia, Distribution, Elimination and Metabolism of Tri-o-cresyl Phosphate Following Daily Oral Administration in Fischer 344 Male Rats , Arch. Toxicol. 1990, 64, 572-579. 

BUTYL-HEXADECYL-SULFIDE DECYL-SULFIDE ETHYL-OCTADECYL-SULFIDE HEPTADECYL-PROPYL-SULFIDE HETHYL-NONADECYL-SULFIDE 1-EICOSANETHIOL DECYL-DISULFIDE TRI-o-CRESYL PHOSPHATE 1-PHENYLPENTADECANE 1-CYCLOPENTYLHEXADECANE 1-CYCLOHEXYLPENTADECANE 1-PHENYLHEXADECANE 1-CYCLOHEXYLHEXADECANE n-BUTYL STEARATE DIISOOCTYL PHTHALATE DIOCTYL PHTHALATE DINONYLPHENOL TETRAPHENYLETHYLENE DIISODECYL PHTHALATE... 

Synonyms AI3-00520 BRN 1892885 CCRIS 6421 o-Cresyl phosphate EINECS 201-103-5 Fyrquel 150 NSC 438 Phosflex 179-C Phosphoric acid, tris(2-methylphenyl) ester Phosphoric acid, tri-2-tolyl ester Phosphoric acid, tri-o-cresyl ester o-TCP TCP TOCP TOFK o Tolyl phosphate TOTP Tricresyl phosphate Triorthocresyl phosphate Tri-2-methylphenyl phosphate Tris(o-cresyl)phosphate Tris(o-methylphenyl)phosphate Tris(o-tolyl)phosphate Tri-2-tolyl phosphate Tri-o-tolyl phosphate. 

Chemical/Physical. Tri-o-cresyl phosphate hydrolyzed rapidly in Lake Ontario water, presumably to di-o-cresyl phosphate (Howard and Doe, 1979). When an aqueous solution containing a mixture of isomers (0.1 mg/L) and chlorine (3 to 1,000 mg/L) was stirred in the dark at 20 °C for 24 h, the benzene ring was substituted with one to three chlorine atoms (Ishikawa and Baba, 1988). 

Benzyl butyl phthalate Benzo [ 6] fluoranthene Benzo [A] fluoranthene Benzol a] pyrene Benzo lei pyrene Tri-o-cresyl phosphate Strychnine Benzo ghi pery lene Indenoll,2,3-crfl pyrene Dibenzo la, A1 anthracene Bis(2-ethylhexyl) phthalate Di-n-octyl phthalate Ammonia... 

Phosphoric acid, triphenyl ester, see Triphenyl phosphate Phosphoric acid, tris(2-methylphenyl) ester, see Tri-o-cresyl phosphate... 

TNT, see 2,4,6-Trinitrotoluene a-TNT, see 2,4,6-Trinitrotoluene TNT-tolite, see 2,4,6-Trinitrotoluene TOCP, see Tri-o-cresyl phosphate TOFK, see Tri-o-cresyl phosphate Tolit, see 2,4,6-Trinitrotoluene Tolite, see 2,4,6-Trinitrotoluene... 

Trimethylnorcamphor, see Camphor Trimethylphenylmethane, see ferf-Butylbenzene Tri-2-methylphenyl phosphate, see Tri-o-cresyl phosphate 1,1,1-Trimethylpropane, see 2,2-Dimethylbutane... 

Chapin RE, Phelps JL, Burka LT, et al The effects of tri-o-cresyl phosphate and metabolites on rat sertoli cell function in primary culture, Toxicol Appl Pharmacol 108 194—204, 1991... 

An example of absolutely cumulative toxicity is afforded by tri-o-cresyl phosphate or TOCP (Fig. 2.13). This compound is a cholinesterase inhibitor and neurotoxin. In chickens, an acute dose of 30 mg /kg has a severe toxic effect, which is produced to the same extent by a dose of 1 (mg/kg)/day given for 30 days. This effect may of course be produced by accumulation of the compound in vivo to a threshold toxic level, or it may result from the accumulation of the effect, as it probably does in the case of TOCP. 

Tri-o-cresyl phosphate shows absolutely cumulative toxicity. Explain this and its implications. 

The toxic effects of tri-o-cresyl phosphate are cumulative such that a dose of 1 mg kg-1 day-1 for 30 days will give the same toxic effects as a single dose of 30 mg kg-1. See text in Chapter 2 for further details and a full explanation. 

Swanson AB, Wagner PA, Ganther HE, et al. 1974. Antagonistic effects of silver and tri-o-cresyl phosphate on selenium and glutathione peroxidase in rat liver and erythrocytes [Abstract], Fed Proc... 

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