Thymic acid

Deoxyribonucleic acids readily undergo hydrolysis whereby purine bases are removed to give a derived polynucleotide originally named thymic acid, but now often called apurinic acid. Hydrolysis may be carried out with dilute mineral acid, but recently apurinic acids have been prepared by fission at room temperature with an acidic, ion-exchange resin.236 Under carefully controlled conditions, removal of the purines can be performed quantitatively without destroying the polynucleotide nature of the material and without altering the inter-pyrimidine ratios of the original material.23 ... 

SYNS P-CYMEN-3-OL 3-p-CYMENOL 3-HYDRO-XY-p-CYMENE 3-HYDROXY-1-METHYL-4-ISOPROP-YLBENZENE ISOPROPYL CRESOL 6-ISOPROPYL-m-CRESOL 2-ISOPROPYL-5-METHYLPHENOL 1-METHYL-3-HYDROXY-4-ISOPROPYLBENZENE 5-METHYL-2-ISOPROPYL-1-PHENOL 5-METHYL-2-(l-METHYLETHYL)PHENOL THYME CAMPHOR THYMIC ACID m-THYMOL... 

Addo trimico 3-p-cymenol p-cymen-3-ol Flavinol 3-hydroxy-p-cymene 3-hydroxy-l-methyl-4-isopropylbenzene Intrasol isopropyl cresol isopropyl-w-cresol 6-isopropyl-m-cresol isopropyl metacresol 2-isopropyl-5-methylphenol 1-methyl-3-hydroxy-4-isopropylbenzene 5-methyl-2-isopropyl-phenol 5-methyl-2-(l-methylethyl) phenol Medophyll thyme camphor thymic acid m-thymol timol. 

Thymol (thymic acid) is extracted from essence of thyme. It is four times more bactericidal than phenol and ten times less toxic. Thymol iodide is used on burns in the same way as iodoform, but has the advantage of not being absorbed and not having any odor. It is less irritating on wounds and mucous membranes than dithymol diiodide or aristol. Thymol iodide powder, an antiseptic that is used often after a phenol peel, physically alters the selective permeability of plasma membranes. It is nevertheless a protoplasmic poison that denatures enzyme proteins and is also an allergen. 

AI3-00708 Caswell No. 856A CCRIS 7299 Cymo-phenol, a- EINECS 201-944-8 ERA Pesticide Chemical Code 080402 FEMA Number 3066 HSDB 866 Isopropyl cresol NSC 11215 Thyme camphor Thymic acid Thymol m-Thymol Thymol (natural). An antibacterial and antifungal agent used in perfumery, microscopy, preservative, antioxidant, flavoring, as a laboratory reagent, in the manufacture of menthol. Used in the prevention of mold and mildew, in flavoring and perfumery, as a preservative and antioxidant and a topical antiseptic. Crystalline solid mp = 51,5° bp = 232.5" dl ... 

Methyl-2-isopropylphenol 5-Methyl-2-(1-methylethyl) phenol Phenol, 5-methyl-2-(1-methylethyl)- Thyme camphor Thymic acid m-Thymol... 

Deoxyribonucleic acids are much more alkali-resistent than ribonucleic acids and require other enzyme systems for hydrolitic degradation. Hydrolysis of deoxyribonucleic acids with mineral acids splits off purine bases, yielding thymic acid and oligonucleotides can be prepared through the action of pancreatic enzymes. 

The enzyme ribonuclease I from pancreas brings about hydrolysis of ribonucleic acids to mono-, di-, tri- and tetranucleotides a large part of the ribonucleic acid remains always imattacked. Ribonuclease I is inactive towards deoxyribonucleic acid but thymic acid suffers partial hydrolysis. 

DNA exhibits rather different properties from RNA in its susceptibility to acid and alkaline hydrolysis. The extreme acid lability of the iV-gly-cosy 1-purine linkages in DNA allows the quantitative liberation of free purines by very mild acid treatment, leaving a high molecular weight residue (called apurinic acid or thymic acid) complete in pyrimidine, deoxy-ribose, and phosphate composition 169), DNA, however, is quite stable to alkaline action since the absence of a hydroxyl group on carbon 2 of deoxy-ribose precludes the possibility of labilization through a cyclic 2, 3 -phos-phate intermediate. 

Finally, in another study related to nutrition and the immune response in the aged, old mice were given oral doses of two amino acids (qv), lysine and arginine. The treated mice showed evidences of recovered mitogenic responsiveness, expression of T-ceU markers, and production of thymic semm factor (thymulin). The effect of the amino acid combination, sold commercially as Neoiodarsolo, seems to consist mainly of the reactivation of the... 

There is no apparent relationship between the amino acid composition of THF and other purified thymic factors. At the present time the primary amino acid sequence of THF has not been established, nor have the cells of origin of THF been identified. 

IV, Thymic humoral Calf polypeptide, 31-amino acid 3200 No — - ... 

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