Isopropyl chloroformate

Chloroformates are shipped in nonretumable 208-L (55-gal) polyethylene dmms with carbon steel overpacks or high density polyethylene dmms. Eor bulk shipments, insulated stainless-steel tank containers and tmcks provide secure protection. Tank tmck and rail car quantities are shipped using equipment dedicated for these types of products. Materials such as isopropyl chloroformate, benzyl chloroformate, and j -butyl chloroformate that require refrigeration are precooled when shipped in bulk containers. Bulk shipments that are precooled must proceed to the destination without layover. Dmm shipments of IPCE, BCE, and SBCE must be shipped in refrigerated containers. Many of the chloroformates are only shipped in tmck load shipments. The U.S. Department of Transportation (DOT) Hazardous Materials Regulations control the shipments of chloroformates, as described in Table 3. 

Isophorone diisocyanate Isopropoxyethanol Isopropyl acetate Isopropyl alcohol Isopropylamine N-lsopropylaniline Isopropyl chloroformate Isopropyl ether... 

The reaction between isopropyl alcohol and phosgene forms isopropyl chloroformate and HC1. In the presence of Fe salts thermal de compn can occur, which in some cases can become expl (Ref 7)... 

Iridium nitratopentamine iridium nitrate Isobutyl isocyanate Isopropyl chloroformate... 

Reacts with vapors of sodium with luminescence at about 260°C. Reacts explosively with thionyl chloride or potassium reacts violently with hexafluoro isopropylidene, amino lithium, ammonia, and strong acids reacts with tert-butyl azidoformate to form explosive carbide reacts with 24-hexadiyn-l, 6-diol to form 2, 4-hexadiyn-l, 6-bischloro-formate, a shock-sensitive compound reacts with isopropyl alcohol to form isopropyl chloroformate and hydrogen chloride thermal decomposition may occur in the presents of iron salts and result in explosion. 

Mixed anhydrides (see Section 2.6) The mixed-anhydride method provides efficient coupling of peptides with minimal isomerization if the established protocol is strictly adhered to. This includes a short activation time at low temperature, isopropyl chloroformate as the reagent, and A-methylmorpho-line or /V-mcthylpipcridinc as the tertiary amine (Figure 2.25, path D). In what is an apparent anomaly with respect to conventional wisdom, a polar solvent such as dimethylformamide seems to be preferable to apolar solvents for minimizing isomerization. Aminolysis at the wrong carbonyl of the anhydride of a peptide (path F) is less than that for the anhydride from the corresponding /V-alkoxycarbonylamino acid. 

NL Benoiton, Y Lee, FMF Chen. Isopropyl chloroformate as a superior reagent for mixed anhydride generation and couplings in peptide synthesis. Int J Pept Prot Res 31, 577, 1988. 

Use the mixed-anhydride method in dimethylformamide with isopropyl chloroformate as me reagent and (V-methylmorpholine, A -melhylpiperi-dine, or trimethylpyridine as me base (see Sections 7.4 and 7.5). 

Isophthaloyl chloride, 2888 f Isopropyl chloroformate, 1560 Methanesullinyl chloride, 0435 Methoxyacetyl chloride, 1165 4-Methoxybenzoyl chloride, 2930 f Methyl chloroformate, 0599 Oleoyl chloride, 3772 Oxalyl dibromide, 0583 Oxalyl dichloride, 0605... 

Further substitution on this compound leads to a somewhat more potent antinema-todal drug. Nitration of (53-6) under the usual conditions leads to the corresponding nitro derivative (54-1). The nitro group is then reduced to the corresponding amine (54-2). Acylation with isopropyl chloroformate forms the corresponding carbamate and thus cambendazole (54-3) [57]. 

Ethylaluminum sesquichloride induces the alkylation of alkenes with isopropyl chloroformate.453 Terminal alkenes [Eq. (5.79)] and cycloalkenes react in the presence of Et3SiH ... 

Isophthaloyl chloride, 2883 f Isopropyl chloroformate, 1555 Methanesulfinyl chloride, 0434 Methoxyacetyl chloride, 1161 4-Methoxybenzoyl chloride, 2925 f Methyl chloroformate, 0732 Oleoyl chloride, 3766 Oxalyl dibromide, 0580 Oxalyl dichloride, 0602... 

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