F Isopropyl chloroformate

Isophthaloyl chloride, 2888 f Isopropyl chloroformate, 1560 Methanesullinyl chloride, 0435 Methoxyacetyl chloride, 1165 4-Methoxybenzoyl chloride, 2930 f Methyl chloroformate, 0599 Oleoyl chloride, 3772 Oxalyl dibromide, 0583 Oxalyl dichloride, 0605... 

Isophthaloyl chloride, 2883 f Isopropyl chloroformate, 1555 Methanesulfinyl chloride, 0434 Methoxyacetyl chloride, 1161 4-Methoxybenzoyl chloride, 2925 f Methyl chloroformate, 0732 Oleoyl chloride, 3766 Oxalyl dibromide, 0580 Oxalyl dichloride, 0602... 

Mixed anhydrides (see Section 2.6) The mixed-anhydride method provides efficient coupling of peptides with minimal isomerization if the established protocol is strictly adhered to. This includes a short activation time at low temperature, isopropyl chloroformate as the reagent, and A-methylmorpho-line or /V-mcthylpipcridinc as the tertiary amine (Figure 2.25, path D). In what is an apparent anomaly with respect to conventional wisdom, a polar solvent such as dimethylformamide seems to be preferable to apolar solvents for minimizing isomerization. Aminolysis at the wrong carbonyl of the anhydride of a peptide (path F) is less than that for the anhydride from the corresponding /V-alkoxycarbonylamino acid. 

F5 Ethylene dichloride Fg Methylene chloride F 7 Chloroform F8 Ethyl ether F9 Ethyl acetate F o n-butyl alcohol F11 Isopropyl alcohol F 2 Acetone F23 Methyl alcohol... 

Like those of biacetyl, the photoreactions of pyruvic acid in solution are entirely different from the reaction in the vapor state. Pyruvic acid is an excellent hydrogen abstractor which is photoreduced to dimethyltartaric acid (27) in isopropyl alcohol, methanol, f-butyl alcohol, chloroform, or diethyl ether.87,88 No reaction was observed in benzene, but photoreduction was... 

Appreciably less information is available for the insertion with CpFe(CO)2R in organic solvents. Both in isopropyl alcohol and in chloroform (Table II), the rate constants decrease in the order R = f-Pr > CH2CMe3 CH2SiMe3 > Me 71, 77). This sequence is significantly different from that obtained by using neat SO2 (see Table I). In particular, the reactivity of CpFe(CO)2Me has been substantially repressed, and that of CpFe(CO)2CH2CMe3 enhanced, relative to those of the other complexes. The order is no longer in harmony with a backside attack of... 

Crystals from isopropyl ether, mp 88-89". ( ) +199.3" (c = 3 in chloroform) [ ][f +230.3 (c = 9 in benzene). Best stored in a vacuum desiccator. Dec on contact with water. One gram dissolves in 20 ml absolute ethanol, more soluble in methanol. Freely sol in ether, chloroform, acetone, ethyl acetate, benzene. Slightly so] in pair ether-... 

Liquid. Slight odor resembling menthol. Pure Decalin does not smell of naphthalene. Volatile with steam. The commercial product may be practically all tram-Decalin, or a mixture contg up to 60% cis-Decalin. The commercial mixture has a flash pt (closed cup) of about 136 F (58 0. Autoignition temp 504 F. lnsol in water very sol in alcohol, methanol, ether, chloroform. Miscible with propyl and isopropyl alcohol miscible with most ketones and esters. LDM orally in rats 4.2 g/kg. Lethal conen for rats in air 500 ppm, Smyth er al.. Arch. Ind. Hyg Occup. Med. 4, 119 (1951). 

PHYSICAL PROPERTIES colorless to yellow liquid weak odor commercial product is a yellow liquid mixture of the cis- and trans isomers miscible with water, benzene, acetone, carbon tetrachloride, chloroform, ethyl and isopropyl alcohols, toluene and xylene practically insoluble in hexane MP (-56°C, -69°F) BP (325°C, 617°F at 760 mmHg) DN (1.25 g/mL at 20°C) LSG (1.25) VD (NA) VP (0.003 mmHg at 20°C) OT (NA). 

Isopropylidenetriphenylphosphorane in tetrahydrofuran mixed with an equimolar amount of ethyl chloroformate, allowed to stand a few hrs., 3 moles n-propyl-magnesium bromide added, and refluxed ca. 5 hrs. isopropyl -propyl ketone. Y 58%. F. e. s. T. Mukaiyama, R. Yoda, and I. Kuwajima, Tetrah. Let. 1969, 23... 

A soln. of dilorine in CCI4 added to a stirred soln. of 5 -diolestane-3), 19-diol in chloroform containing pyridine, after 15 min. a little isopropyl alcohol added, and the product isolated after an additional 5 min. -> 5 -diolestan-19-ol-3-one. Y almost 100%. F. e., also oxidation to aldehydes, s. J. Widia and A. Zarecki, Tetrah. Let. 1974, 3059. 

Acylcyanides. Dry HCl passed 5-8 min. with stirring into a soln. of phenacyl-triphenylphosphonium chloride in dry chloroform, isopropyl nitrite added por-tionwise during 3-7 hrs. with continued passage of HCl, stirred an additional 0.5 hr., and allowed to stand 12 hrs. without passage of HCl (benzoylnitroso-methyl)triphenylphosphonium chloride (Y 96%) dissolved in abs. alcohol, a soln. of Na-ethoxide in alcohol added with stirring, and the product isolated after 20 min. -> phenylglyoxylonitrile (Y 72%). F. e. s. M. I. Shevchuk, E. M. Volynskaya, and A. V. Dombrovskii, aC. 41, 1999 (1971) C. A. 76, 34355. 

A soln. of N-isopropyl-p-nitrophenylglyoxyl imidochloride in benzene-chloroform said, with hydrogen sulfide N-isopropyl-p-nitrophenylglyoxyl thio-amide. Y 87%. F. e. s. W. Walter and K.-D. Bode, Ang. Gh. 74, 694 (1962). 

A soln. of isopropyl methylphosphonofluoridate in chloroform added slowly to a soln. ethanolamine and triethylamine in the same solvent, and stored 2 days isopropyl 2-aminoethyl methylphosphonate. Y 71%. - Ghloridates and other phosphylation agents give predominantly N-phosphylation. F. e. s. R. Green-halgh and M. A. Weinberger, Gan. J. Chem. 45, 495 (1967). 

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