Isopropyl isocyanate

B. Polymeric Urea [Benzene, diethenyl-, polymer with ethenylbenzene, [[[[(1 methylethyl)amino]carbonyt]amino]methyl] deriv.] A 10.0-g. portion of benzylamine polymer beads prepared as in Part A and 125 ml. of tetrahydrofuran (Note 6) are combined in a 300-ml., three-necked, round-bottomed flask equipped with a magnetic stirrer, a dropping funnel, and a condenser fitted with a gas-inlet tube A nitrogen atmosphere is established in the system, and the slurry is stirred while 1.35 g. (0.0159 mole) of isopropyl isocyanate [Propane, 2-isocyanato-] is added. This causes an exothermic reaction, which subsides after about 20 minutes. The mixture is then stirred at room temperature for 22 hours and at reflux for an additional 4 hours. The beads are collected by filtration, washed with 150-ml. portions of tetrahydrofuran (Note 6) and methanol, and dried under reduced pressure over calcium chloride to yield 9.09 g, of the isopropyl urea polymer. 

Isopropylbenzalde hyde, 55, 10 Isopropyl ether, 58, 45, 52 Isopropyl fluoride, S8, 78 Isopropyl isocyanate, 56, 96 l-Isopropyl4-methjrlcyclohexene, 59,47... 

Isopropylcumyl hydroperoxide, >72% in solution Isopropyl isocyanate Isothiocyanic acid... 

Data of time-temperature-rate were obtained in a differential packed reactor for the thermal decomposition of isopropyl isocyanate (Fogler, 1992). Find a rate equation. 

Regioselective substitution reactions of a series of 2- and 3-hydroxybiaryls including BINOL have been performed via a new directed orf/io-metallation procedure.75 O-Aryl AMsopropylcarbamates, conveniently prepared from phenols and isopropyl isocyanate, have been temporarily and in situ N-protected by means of silyl inflates to form stable intermediates for low-temperature lithiation reactions using n-BuLi-TMEDA in diethyl ether. The IV,IV-dialkyl aryl O-sulfamate has been reported as a new directed metallation group.76... 

Analytical Properties Separation of bopindolol and also separation of pindolol after derivatization with isopropyl isocyanate separation of dl mixtures of enantiomers can be used on both the analytical and preparative scales changes in pH will cause this phase to leach from the column storage at 4°C is recommended Reference 1,2... 

Reaction of 1 with 2,4,6-tri-t-butylbenzoyl chloride formed a 2,3-diphosphabuta-l,3-diene as well as a phosphaethyne (equation 5)20. An amino-substituted phosphaethyne was prepared starting from 1 and isopropyl isocyanate by an addition-elimination-silatropy reaction (equation 6)21. Addition of 1 to kinetically stabilized phosphaketene (see Section HI) gave a 1 1 adduct22 or a 1 2 adduct23 the former was converted to 1,3-diphospha-buta-1,3-dienes by treatment with acyl chlorides (equation 7)22. Both adducts could be converted to the same 1,2,4-triphosphabuta-l,3-diene23,24. 

The Step 5 product (300 mg) dissolved in 3 ml CH2C12 at 0°C was treated with NaH (21.6 mg), then stirred 30 minutes at ambient temperature, then further treated with 0.288 ml isopropyl isocyanate, and stirred additional 5 hours at ambient temperature. The mixture was diluted with water, extracted with EtOAc, washed with 1M NaOH solution, brine, dried, and concentrated. The residue was recrystallized from EtOAc/hexane and 315 mg product isolated as a colorless crystal powder. 

Polymers with pendant carbodiimide groups 27 are also synthesized from crossUnked polystyrene. In this synthetic route crossUnked polystyrene beads are chloromethylated and converted to the amines. Reaction with isopropyl isocyanate gives the corresponding ureas, which are treated with tosyl chloride and triethylamine to produce the crossUnked polycarbodiimides. This polymer is used in the polymer supported Moffatt oxidation of alcohols into aldehydes or ketones using benzene/DMSO. ... 

It reacts with zinc oxide (1, 1294 additional suppliers Alfa Inorganics, ROC/RIC) to give isopropyl isocyanate (S). The yield is high if the complex (I) is not isolated owing to its high sensitivity to moisture. The reaction of (I) with silver oxide was not successful owing lo the violence of reaction. Reaction of (I) with sodium acetate gave (S) in 24% yield. 

P5-15c The thermal decomposition of isopropyl isocyanate was studied in a differential packed-bed reactor. From the data in Table P5-15, determine the reaction law parameters. 

---