Irritancy pharmaceutical gastrointestinal

Sulfonic Acids. Drugs that contain sulfonic acids are quite acidic. They have high water solubility and are rapidly excreted, leading to a rather short half-life. They can also be irritating to the gastrointestinal tract during the pharmaceutical phase. 

Chemical/Pharmaceutical/Other Class Actaea species, of the order Ranunculaceae Gastrointestinal irritants... 

Microencapsulation is common in pharmaceutical industry, particularly when sustained release of a medication is required. Ethyl cellulose is a common coating material. Most capsules are formed by solvent evaporation, polymer-polymer phase separation, or fluidized-bed coating process. Common examples of encapsulated drugs include aspirin, acetaminophen, ampidlhn, and potassium chloride. Orally administered capsules serve to conceal an unpleasant taste and reduce gastrointestinal irritation that can be caused by oral unencapsulated drug. 

Toxicology Applic. to skin may cause allergic reaction ingestion results in violent gastrointestinal irritation Uses Colorant in foods, cosmetics, hair dyes, eye makeup, soap, external pharmaceuticals incl. those for eye area use pigment in water-based paints... 

Poly(ethylene oxide) resins are safely used in numerous pharmaceutical and personal care applications. Poly(ethylene oxide) resins show a low order toxicity in animal studies by all routes of exposure. Because of their high molecular weight, they are poorly adsorbed from the gastrointestinal tract and are completely and rapidly eliminated (104). The resins are not skin irritants or sensitizers, nor do they cause eye irritation. 

Both German chamomile and Roman chamomile extracts are used in pharmaceutical preparations, with the former more frequently used they are used in antiseptic ointments, creams, and gels to treat cracked nipples, sore gums, inflammations, irritation of the skin and mucosa, respiratory tract inflammation, and for wound healing. The volatile oils are used in carminative, anti-spasmodic, and tonic preparations, among others. An infusion or tincture of the flower-heads is used for gastrointestinal spasms, inflammatory conditions of the gastrointestinal tract, and peptic ulcers, menstrual disorders, in addition to mild sleep disorders, especially in children (bradly Escop 1 wichtl). ... 

The case studies will also consider situations where chemists have addressed the problem of irritancy to the gastrointestinal tract by making appropriate analogues. As a pharmaceutical chemist, because one will be able to relate the medicinal chemistry to the dmg s pharmacokinetics and pharmacodynamics, one will not only be able to understand why a patient needs a particular dmg, but what the best way to administrate it is, what dose and duration of action to expect (and why this is so), and why it elicits its effect. By understanding the medicinal chemistry of dmgs, from a pharmacokinetics perspective, one will be able to explain ... 

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