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Ion trap collisional activation

Cargile, B. J. McLuckey, S. A. Stephenson, J. L. Identification of bacteriophage MS2 coat protein from E. coli lysates via ion trap collisional activation of intact protein ions. Anal. Chem. 2001, 73,1277-1285. [Pg.275]

Pitteri, S.J. Chiisman, P.A. Badman, E.R. McLuckey, S.A. Charge-state dependent dissociation of a trypsin/inhibitor complex via ion trap collisional activation. Int. J. Mass Spectrom. 2006,253,147-155. [Pg.29]

Schaaff TG, Caigile BJ, Stephenson JL, McLuckey SA. Ion trap collisional activation of the (M + 2H)2+-(M +17H) Hons of human hemoglobin B-Chain. Anal Chem. 2000 72( 5 ) 899-907. [Pg.48]

Low-energy CID is frequently further divided into beam-type CID and ion trap-type CID where the latter type involves lower collision energies than the former. This division is clarified in Figure 16.1 (reproduced from an excellent CID review by McLuckey and Goeringer ), which shows that ion trap collisional activation (CA) and ICR-sustained off-resonance irradiation (SORI) CA (both of which involve multiple collisions) occur over much longer timescales than CA from <100-eV multiple collisions in a beam-type instalment (e.g., a triple quadrupole or hybrid quadrupole/TOF configuration). Thus, each collision imparts less energy in ion trap-type CID compared to beam-type CID. This... [Pg.574]

Both collisional activation (in ion traps) and post source decay (in curved field reflectron TOF analyzers) have been used successfully to obtain sequence ions from peptides prepared in situ on the sample holder. Single Dalton mass windows are advantageous for precursor selection, as are realized in ion-trap and trap-TOF configurations. Publicly available search algorithms can be used... [Pg.266]

TD-IT, Thermal desorption-ion trap CAD MIKE, collisionally activated decomposition mass-analyzed ion kinetic energy MID, multiple ion detection FID, flame ionization detector NPD, nitrogen/phosphorus detector SIM, selected ion monitoring El, electron impact TMS, trimethylsilane MTBSTFA, N-methyl-N-(tetr.-butyldimethylsilyl)trifluoroacetamide. [Pg.1024]

Because of the importance of the biphenyl scaffold, as a structure of pharmaceutical and active therapeutic compounds, the mass spectrometric behavior of a series of 6,6-disubstituted dibenzo[r//][l,3]dioxepins 36 has been studied. The electron ionization-induced fragmentation patterns were discussed based on use of labeled compounds, accurate mass measurements, and collisionally induced dissociation experiments using an ion trap <2006JMP577>. [Pg.328]

Wan, K.X. Gross, M.L. Shibue, T. Gas-Phase Stability of Double-Stranded Oligodeoxynucleotides and Their Noncovalent Complexes with DNA-Binding Drugs as Revealed by Collisional Activation in an Ion Trap, J. Am. Soc. Mass Spectrom. 11,450 57 (2000). [Pg.59]

Sulfatides (3-sulfogalactosylceramides) were initially detected by mass spectrometry using FAB ionization but spectrum showed a number of fragmentations which complicates considerably the method (Ohashi and Nagai, 1991). More recently structural characterization of sulfatides by collisional-activated dissociation (CAD) was described in quadrupole ion-trap tandem mass spectro-metric methods with electrospray ionization. With the method [M - H]- ions of sulfatides yield abundant structurally informative ions that permit unequivocal assignments of the long-chain base and fatty acid constituent including the location of double bond (Hsu and Turk, 2004). The major sulfatide molecular species are quantified similarly in the 2 clinical forms (motor and... [Pg.578]

Fischer carbenes can be generated from diazomalonates in the gas phase, as reported by Beauchamp and co-workers. Suitable cations for study were obtained by electrospray of solutions of Ag or Cu salts with the diazoma-lonate 21 in methanol water acetonitrile (80 20 0.1). The further reaction steps were conducted in a quadrupole ion trap spectrometer. Complexes formed via electrospray first undergo Fischer carbene formation and subsequently Wolff rearrangement upon collisional activation. Experiments with isotopically labeled diazomalonates suggest the underlying mechanism shown in Scheme 8. [Pg.814]

The electrospray ionisation mass spectrometric analyses were performed using a Finnigan LCQ ion trap mass spectrometer. The samples were dissolved in methanol or chloroform methanol system (10 1 v/v) and such solutions were introduced to the ESI source by continuous infosion by means of the instrument syringe pmnp with the rate of 3 iL/min. The ESI source was operated at 4.25 kV and the capillary heater was set to 200°C. For ESI-MS" experiments mass selected mono-isotopic parent ions were isolated in the trap and collisionally activated with 33% ejection RF-amplitude at standard He pressure. The experiments were performed in the positive and negative-ion mode. [Pg.342]

Tandem mass spectrometry (MS/MS), in its simplest and earliest implementations on quadrupole ion traps (QlTs), employed sequential (tandem-in-time MS/MS) isolation and energetic (for example, collisional) activation steps [16-22]. Modem MS/ MS experiments can involve multiple stages of mass selectivity (MS"), which employ different dissociation methods. Depending upon precursor chemistry, sometimes... [Pg.60]

Brodbelt, J.S. Kenttamaa, H.I. Cooks, R.G. Energy-resolved collisional activation of dimethyl phosphonate and dimethyl phosphite ions in a quadrupole ion trap and a triple quadrupole mass-spectrometer. Org. Mass Spectrom. 1988, 23, 6-9. [Pg.74]

Gronowska, J. Paradisi, C. Traldi, P. Vettori, U. A study of relevant parameters in collisional-activation of ions in the ion-trap mass spectrometer. Rapid Commun. Mass Spectrom. 1990,4,306-314. [Pg.385]

In this study, the level of scrambling at different CID fragmentation amplitudes was monitored in the model peptide PI (HHHHHHIIKIIK) with a regioselective deuterium labeling that is a sensitive probe for H/D scrambling (see Section 8.2.3) [43]. In a 3D quadrupole ion trap instrument, the triply charged peptide was subjected to various degrees of RF-induced collisional activation followed by... [Pg.129]

M. C. Crowe and J. S. Brodbelt, Infrared multi-photon dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap (QIT) with selective IRMPD of phosphopeptides, J. Am. Soc. Mass Spectrom. 15, 1581-1592, (2004). [Pg.147]

Greaser, C.S. and O Neill, K.E. (1997) Photodissodation and collisionally activated dissodation tandem mass spectrometric studies of difluoro[triazol-l-ylmethyl]benzhydrols and related compounds in a quadruple ion trap. Int. J. Mass Spectrom. Ion Processes, 165, 13-23. [Pg.102]


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See also in sourсe #XX -- [ Pg.94 , Pg.95 ]




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Collisional

Collisional activation

Ion activity

Ion trap

Ion trapping

Ion-activated

Trapped ions

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