Ion Spray Mass Spectrometry

Lee, E. D., Mueck, W., Henion, J. D., and Covey, T. R. (1989). Liquid junction coupling for capillary zone electrophoresis/ion spray mass spectrometry. Biomed. Environ. Mass Spectrom. 18, 844—850. 

Sheppard, R. L., Tong, X., Cai, J., and Henion, J. D. (1995). Chiral separation and detection of terbutaline and ephedrine by capillary electrophoresis coupled with ion spray mass spectrometry. Anal. Chem. 67, 2054-2058. 

Von Brocke, A., Wistuba, D., Gfrorer, P., Stahl, M., Schurig, V, and Bayer, E. (2002). On-line coupling of packed capillary electrochromatography with coordination ion spray-mass spectrometry for the separation of enantiomers. Electrophoresis 23, 2963 — 2972. 

Lim, H.-K., Hsieh, Y.L., Ganem, B., Henion, J. Recognition of cell-wall peptide ligands by vancomycin group antibiotics studies using ion spray mass spectrometry. J. Mass Spectrom. 1995, 30, 708-714. 

C Rentel, P Gfrorer, E Bayer. Coupling of capillary electrochromatography to coordination ion spray mass spectrometry, a novel detection method. Electrophoresis 20 2329-2336, 1999. 

ESI-MS has been used for the quantification of a number of substrates and products of enzymatic reactions [56,57]. Hsieh et al. report the use of ion spray mass spectrometry (a technical variation of electrospray ionization) coupled to HPLC for the kinetic analysis of enzymatic reactions in real time [58]. The hydrolysis of dinucleotides with bovine pancreatic ribonuclease A and the hydrolysis of lactose with 3-galactosidase were monitored and the resulting data were used for the estimation of and v x of these reactions. Another field of application of electrospray mass spectrometry is the screening of combinatorial libraries for potent inhibitors [31,59]. 

Careri, M., Elviri, L., and Mangia, A., Validation of a liquid chromatography ion spray mass spectrometry method for the analysis of fiavanones, flavones and flavonols. Rapid Commun. Mass Spectrom., 13, 2399, 1999. 

Fulcrand, H. et al.. Study of the acetaldehyde induced polymerisation of flavan-3-ols by liquid chromatography ion spray mass spectrometry. J. Chromatogr. 752, 85, 1996. 

Nedved, M. L. Habibi-Goudarzi, S. Ganem, B. Henion, J. D. 1996. Characterization of benzodiazepine combinatorial chemical libraries by on-line immunoaffinity extraction, coupled column HPLC-ion spray mass spectrometry-tandem mass spectrometry. Anal. Chem., 68, 4228-4236. 

L. G. McLauglin and J. D. Henion, Determination of aminoglycoside antibiotics by reversed-phase ion-pair high-performance liquid chromatography coupled with pulsed amperometry and ion spray mass spectrometry, J. Chromatogr., 597 195-206 (1992). 

Alkyl sulphonates and alkylethyl sulphonates Ion spray mass spectrometry [19]... 

M.A. Quilliam, B.A. Thomson, G.J. Scott and K.W.M. Siu, Ion-spray mass spectrometry of marine neurotoxins, Rapid Commun. Mass Spectrom., 3, 145-150 (1989). 

J. J. Corr, Measurement of molecular species of arsenic and tin using elemental and molecular dual mode analysis by ion spray mass spectrometry, J. Anal. Atom. Spectrom., 12 (1997), 537-547. 

Pleasence, S., Quilliam, M.A., DE Freitas, A.S.W., Marr, J.C., and Cembella, A.D. 1990. Ion-spray mass spectrometry of marine toxins. II. Analysis of diarrhetic shellfish toxins in plankton by liquid chromatography/mass specfi omefiy. Rapi Commun Mass Spectrom 4,206-213. 

Nicolaou KC. Evidence of Ca -dependent carbohydrate association through ion spray mass spectrometry. J. Am. Chem. Soc. 1993 115 2877-2881. 40. 

JW Metzger, K-H Wiesmiiller, V Gnau, J Briinjes, G Jung. Ion spray mass spectrometry and multiple sequence analysis of synthetic peptide libraries. Angew Chem Int. Ed Eng 32(6) 894-896, 1993. 

B Ganem, JK Henion. Detecting noncovalent complexes of biological macro-molucules new applicants of ion-spray mass spectrometry. Chemtracts Org Chem 6 1-22, 1993. 

Gaub M, von Brocke A, Ross G, Kovar KA. High-performance liquid chromatography-coordination ion spray mass spectrometry (HPLC-CIS/MS) a new tool for the analysis of non polar compound classes in plant extract using the example of Piper methysticum Forst. Phytochem Anal 2004 15 300-305. 

Popenoe, D. D., Morris, S. J., Horn, P. S., and Norwood, K. T., Determination of alkyl sulfates and alkyl ethoxysulfates in wastewater treatment plant influents and effluents and in river water using liquid chromatography/ion spray mass spectrometry. Anal. Chem., 66, 1620-1629, 1994. 

Another quaternary alkyl piridinium salt (36) was isolated from an extract of the Micronesian sponge Callyspongia fibrosa [37]. A cyclic structure for this compound was first proposed on the basis of ion-spray mass spectrometry. However, a theoretically identical sample (36a) produced by an efficient synthetic route (see Scheme 7) revealed that the EGF active constituent must be a large oligomer or polymer of (36). 

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