Combinatorial chemical libraries

W Zheng, SI Cho, A Tropsha. Rational combinatorial library design 1. Focus-2D A new approach to the design of targeted combinatorial chemical libraries. J Chem Inf Comput Sci 38 251-258, 1998. 

Teopsha, a., Cho, S.)., Zheng, W. New Tricks for an Old Dog development and application of novel QSAR methods for rational design of combinatorial chemical libraries and database mining. In Rational Drug Design Novel Methodology and Practical Applications, ACS Symposium Series Vol. 719, Paeeill,... 

The recent development of parallel and combinatorial chemical library synthesis has created a renewed interest in polymeric solid-phase reagents. They offer the advantage of... 

Tropsha, A., Zheng, W., and Cho, S. J. (1996) Application of topological indices in rational design of combinatorial chemical libraries. Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 22-28, American Chemical Society Washington, DC. 

Fig. 7. Screening plates with yeast SKY54 Ras-Raf, SKY54 hsRPB4-hsRPB7, and SKY48 Ras-Raf strains incubated with the 96 compounds from combinatorial chemical library. The area with putative Ras-Raf inhibitors and individual antifungal compounds is indicated by frame or by arrow, respectively. Note increased size of death zones for some compounds on SKY54 vs SKY48 plates.

Nedved, M. L. Habibi-Goudarzi, S. Ganem, B. Henion, J. D. 1996. Characterization of benzodiazepine combinatorial chemical libraries by on-line immunoaffinity extraction, coupled column HPLC-ion spray mass spectrometry-tandem mass spectrometry. Anal. Chem., 68, 4228-4236. 

Besides classical resin beads, other polymeric carriers were also used for the synthesis ofpeptide libraries in various formats. Poly aery late-grafted polypropylene pins were used for the synthesis of the first combinatorial chemical library [1,2], This type of support continues to be heavily used in multiple peptide [27] and non-peptide [28] library synthesis. Cellulose paper, originally used by Frank et al. as a solid-phase support for oligodeoxy-ribonucleotide synthesis [29], has also been used as the support for multiple SPOT synthesis of peptide libraries [30,31], Polystyrene-grafted polyethylene film (PS-PE) may also be used in combinatorial peptide library synthesis [32], The specific feature of the membrane type of carrier is its dividability. This feature has been used for the synthesis of libraries with a nonstatistical distribution of library members, where no compound is missing and none is represented more than once [33],... 

Erb E, Janda KD, Brenner S, Recursive deconvolution of combinatorial chemical libraries, Proc. Natl. Acad. Sci. USA, 91 11422-11426, 1994. 

Deprez, B, Williard X, Bourel L, Coste H, Hyafil F, Tartar A, Orthogonal combinatorial chemical libraries, J. Am. Chem. Soc., 117 5405-5406, 1995. 

Zheng, W., Cho, S.J. and Tropsha, A. Rational Combinatorial Library Design. 1. Focus-20 A New Approach to the Design ofTargetted Combinatorial Chemical Libraries. J. Chem. Inf. Comput. Set, 1998, 38, 251-258. 

Abstract A combinatorial chemical library is a (usually large) set of compounds made... 

Vaino AR, Janda KD (2000) Euclidean shape-encoded combinatorial chemical libraries. Proc Natl Acad Sci USA 97 7692... 

M.L. Nedved, S. Habibi-Goudarzi, B. Ganem, J.D. Henion, Characterization of benzodiazepine combinatorial" chemical libraries by on-line lAC, coupled column LC-ESI-MS-MS, Anal. Chem., 68 (1996) 4228. 

E Erb, KD Janda, S Brenner. Recursive deconvolution of combinatorial chemical Libraries. Proc Nad Acad Sci USA 91 11422-11426,1994. 

B Deprez, X Williard, L Bourel, H Coste, F Hyafil, A Tartar. Orthogonal combinatorial chemical libraries. J Am Chem Soc 117 5405—5406,1995. 

Several reports published within the year describe new photocleavage protecting groups. The accounts by Misetic and Boyd, and Giegrich et al. outline such mechanisms for primary alcohols and in nucleoside/nucleotide systems respectively, while the work of Akerblom et al. is relevant to the synthesis of combinatorial chemical libraries on solid phases and that of McGall et al. is of use in the solid phase synthesis of polypeptides and oligonucleotides. 

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