Inula britannica

Je KH, Han AR, Lee HT, Mar W, Seo EK. The inhibitory principle of lipopolysaccha-ride-induced nitric oxide production from Inula britannica var. chinensis. Arch Pharm Res 2005 27 83-85. 

Lee HT, Yang SW, Kim KH, Seo EK, Mar W. Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase. Arch Pharm Res 2002 25 151-153. 

Inula britannica L. I. japonica Thunb. I. linariaefolia Turcz. I. linariaefolia Turcz. f. simplex Kom. I. salsoloides (Turcz.) Ostenfeld Xuan Fu Hua (Elecampane) (aerial part, including flower head) Inusterol A, taraxasterol, inusterol B, inulicin, flavone, caffeic acid, chlorogenic acid, isoquercitrin, quercetin, taraxasteryl palmitate, bigelovin, dihydrobigelovin.48-50 260 Discutient, vulnerary, antiemetic, carminative, diuretic, deobstruent, treat ascites, bronchitis, cancer, chest congestion. 

Inula britannica L., I. japonica Thunb., I. salsoloides (Turcz.) Ostenfeld, I. linariaefolia Turcz., I. linariaefolia Turcz. f. simplex Kom. 

Forsythia suspensa, Inula britannica, I. japonica, I. linariaefolia, I. salsoloides Ginkgo biloba Ginkgo biloba... 

C. grandiflora, Codonopsis pilosula, C. tangshen, C. ussuriensis, Cirsium chinense, C. japonicum, Lappa communis, L. edulis, L. major, L. minor, Senecio vulgaris, Taraxacum formosanum, T. officinale Inula britannica, I. japonica, I. linariaefolia, I. salsoloides... 

Achillea millefolium, Anethum graveoleus, Aspidium filix-mis, Aster tataricus, Calendula officinalis, Dryopteris filix-mas, Inula britannica, I.japonica, Lycopodium clavatum, L. obscurum, Myrica cerifera, M. penxylvanica, Peucedanum graveolens, Sambucus nigra, S. canadensis Melia azedarach... 

Ergolide (sesquiterpene lactone) Inula britannica (Asteraceae) l iNOS expression [per NFkB inactivation]... 

Sqll9 Ergolide Inula britannica COX, iNOS, NFkB [179]... 

Syn Inula britannica L. var. japonica (Thunb.) Franch. Sav. PN xuanfu hua (flower)... 

Documented effects In modem medicine Inula britannica is used the same way as Inula helenium (Khodzhimatov 1989). Flavonoids isolated from this species were shown to protect cultured rat cortical cells from cell death caused by oxidative stress (Kim et al. 2002). Results from experiments with mice suggest an aqueous extract from the flowers of Inula britannica p.japonica Kitam. has a preventative effect on autoimmune diabetes by regulating cytokine production (Kobayashi et al. 2002b). The sesquiterpene lactone ergolide has anti-inflammatory activity (Han et al. 2(X)1). 

A Inula britannica L. Photos Sergey Appolonov T Inula helenium L. Photos Sergey Mayorov... 

Kobayashi A, Hachiya A, Ohuchi A, Kitahara T, Takema Y (2002a) Inhibitory mechanism of an extract of Althaea officinalis 1. on endothe-hn-l-induced melanocyte activation. Biol Pharm BuU 25(2) 229 Kobayashi T, Song QH, Hong T, Kitamura H, Cyong JC (2002b) Preventative effects of the flowers of Inula britannica on autoim-... 

Zhou BN, Bai NS, Lin LZ, Cordell GA (1993) Sesquiterpene lactones from Inula Britannica. Phytochemistry 34(l) 249-252... 

Three New Sesquiterpene Lactones from Inula britannica... 

Three new sesquiterpene lactones were identified from the flowers of Inula britannica var. chinensis britannilide, oxobritannilactone and eremobritanilin. Their structures were established by spectroscopic methods. Britannilide and eremobritanilin inhibited the growth of human P388 cell lines. 

Inula, from Compositae, has more than 100 species in the world, mainly found in Europe, Africa and Asia. There are more than 20 species in China. Inula britannica is a wild plant found in Eastern Asia, including China, Korea, and Japan. In traditional Chinese medicine. Inula britannica and Inula japonica are called Xuanfiihua and the flowers have been used for the treatment of digestive disorders, bronchitis and inflammation. Its extracts are reported to have anti-inflammatory, anti-bacteria, anti-hepatitis and anti-tumorigenic activities ) ... 

In our previous studies on Chinese Inula species, we isolated sesquiterpene lactones from Inula britannica (2), I. salsoloides (i), I. hupehensis and I. 

The flowers of Inula britannica var. chinensis were collected in July 1990 during the flowering stage, at the suburb of Yanan City, Shanxi Province, China. It was identified by Professor Tian-Lang Pan, Yanan Institute of Medicine Inspection, Shanxi Province, China. Voucher specimens are deposited in the Laboratory of Phytochemistry, Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, China. 

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