Pancreatic intraepithelial neoplasia

In order to identify new molecular markers of the pancreatic tumor progression we established a proteomics approach analyzing 1000 microdissected cells from different pancreatic intraepithelial neoplasias (PanIN) grades (Sitek et al., 2005b). 

Figure 3.8 Histological images of different PanIN grades stained with H E. It is believed that pancreatic intraepithelial neoplasias (PanINs) are the precursor lesions of pancreatic ductal adenocarcinoma (PDAC). PanINs are histologically subdivided into four different grades, namely PanIN-lA/B,...

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Prasad NB, Biankin AV, Eukushima N, et al. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res. 2005 65 1619-1626. 

Tomaszewska R, Okon K, Nowak K, Stachura J. HER-2/Neu expression as a progression marker in pancreatic intraepithelial neoplasia. Pol J Pathol. 1998 49 83-92. 

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