Configuration Specification

Safety Monitor is an interactive computer program (Stamm, 1996) that performs real-time assessments of configuration-specific plant accident risk. Originally used at Southern California Edison s San Onofre station in 1994, further development was sponsored by three nuclear utilities and EPRI, to include shutdown operation and expanded user features. It will be enhanced to calculate large early release frequency (a Level 2 risk). 

An enzyme consists of a polypeptide chain with a particular spatial configuration specific to that sequence of amino acids. The molecule twists and turns, forming structural features that are catalytically active, these being known as active sites. There may be more than one active site per enzyme molecule. Sometimes an auxiliary catalyst, known as a coenzyme, is also needed. Apparently, only the relevant active site of the enzyme comes into contact with the substrate and is directly involved in the catalysed reaction. The active site consists of only a few amino acid residues. These are not necessarily adjacent to one another in the peptide chain but may be brought into proximity by the characteristic folding of the enzyme structure. The active site may also include the coenzyme. The remainder of the enzyme molecule fulfils the essential function of holding the components of the active site in their appropriate relative positions and orientation. 

Pressure detection shall be used for closed enclosure applications. Threshold detectors provide an electric signal when a preset overpressure is exceeded. Dynamic detectors provide an electric signal to the control and indicating equipment (CIE). Typically they have both rate-of-rise and pressure threshold triggering points that can be configured specifically to the application conditions. Although this type of detector minimizes spurious activation of the isolation system (due to pressure fluctuations other than explosion pressure rise), care shall be taken to set up such detectors to meet appropriate detection response criteria for the particular application and protected enclosure geometry. 

For configurational specification of phospholipids as recommended by the lUPAC-IUB Commission on Biochemical Nomenclature, see Biochim. Biophys. Acta 1968, 152, 1-9. 

Curro and Mark 38) have proposed a new non-Gaussian theory of rubber elasticity based on rotational isomeric state simulations of network chain configurations. Specifically, Monte Carlo calculations were used to determine the distribution functions for end-to-end dimensions of the network chains. The utilization of these distribution functions instead of the Gaussian function yields a large decreases in the entropy of the network chains. 

The final integrated hardware/software system must achieve a full IQ to verify that the predetermined hardware and software configuration specifications are satisfied. Be sure to verify that the software version installed on the final system is the same as the one used for OQ testing on the pilot system. If not, there must be formal change control documentation in place that verifies that the validated status of the software has not been affected. There must also be some operational testing done on the final system. If the validation plan has identified the need for IQ, OQ, and PQ, it would be reasonable to perform the OQ on the pilot system and PQ on the final system. If only IQ... 

R de Souza Pereira, F Pavao, G Oliva, The use of molecular modelling in the understanding of configurational specificity (R or S) in asymmetric reactions catalyzed by Saccharomyces cerevisiae or isolated dehydrogenases. Mol Cell Biochem 178 27-31, 1998. 

The interblock communication can be implemented several ways, depending on the manufacturer. One way is to configure specific forward and backward connections as shown in Figure 2.46. The forward connections are as follows ... 

In principle at least, Eq. (7.14) provides the basis for a complete calculation of the configuration-specific rheological properties of the suspension at each given instant of time t. In order to calculate therefrom the time-averaged properties of the suspension, consider the macroscopic simple shear flow discussed previously in connection with Fig. 4. 

Calculations have thus far been performed for the three standard cubic arrays, namely simple cubic (sc), body-centered cubic (bcc), and face-centered cubic (fee). As a result of this geometric symmetry, the couple N and particle stress dyadic A are given by the configuration-specific relations... 

An overbar denotes coarse-grained quantities. The Newtonian constitutive Eq. (8.20c), in effect, defines the configuration-specific, anisotropic, kinematic viscosity-tetradic T (=vijkl) of the spatially periodic suspension. Subject to the attenuation conditions,... 

Equation (8.22) constitutes the means whereby the configuration-specific kinematic viscosity of the suspension may be computed from the prescribed spatially periodic, microscale, kinematic viscosity data v(r) by first solving an appropriate microscale unit-cell problem. Its Lagrangian derivation differs significantly from volume-average Eulerian approaches (Zuzovsky et al, 1983 Nunan and Keller, 1984) usually employed in deriving such suspension-scale properties. 

D1.3 Are documented configuration specifications in place for each network component (e.g., Mainframes, Servers, Storage Devices, Transceivers, Repeaters, Bridges and Renters, etc.) ... 

Galano, J. M., Audran, G., Monti, H. First enantioselective total synthesis of both enantiomers of lancifolol. Correlation absolute configuration/specific rotation. Tetrahedron Lett 2001,42, 6125-6128. 

In the present context, we have denoted the defect coordinates using the set ( r ), while the set r, is the associated set of velocities. The second part of the argument is to find Arose r, s that minimize IT. What this means is that at a fixed configuration (specificed by the parameters ( r )), we seek those generalized velocities which are optimal with respect to 0. A dynamics of the degrees of freedom ( r, ) is induced through an appeal to the variational statement 50=0. Since our aim is to find velocity increments to step forward in time from a given... 

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