Integral life cycle management

A first obvious consequence of such considerations is that we should not only look at the costs of the product from an economic point of view, but that we must consider the costs of the production process in a broader sense. We must take into account the raw materials used, the amount of energy invested and the possibility to design alternatives, more environmentally friendly processes. In other words, we should not only look at the desired product, but we must consider the total life cycle of the product The design of a production process taking into account these aspects is often referred to as integral life cycle management. 

Labuschagne, C., and Brent, A., 2004. Sustainable project life cycle management The need to integrate life cycles in the manufacturing sector, International Journal of Project Management, 23 (2), 159-168. 

Integrated Drug Product Development — From Lead Candidate Selection to Life-Cycle Management... 

Guidances recommend an integration of software life-cycle management and risk management activities. Software validation and verification activities must be conducted throughout the software life cycle [12,14]. Software verification and validation are terms frequently confused. Software verification is defined as the process that provides objective evidence that the design outputs of a particular phase of the software development life cycle meet all of the specified requirements for that phase... 

Once the project is completed, the aspects of Part 11 have to be integrated routinely into the system life cycle management. During the system life cycle Part 11 impacts on several steps ... 

The framework of Westkamper et al. takes up the principle of sustainable business and the consideration of the entire product life cycle. Its vision is to regard technical products or machines over their entire life cycle (see Fig. 1). In doing so, the provision of consistent data and information on the entire life cycle is of special importance (Westkamper et al. 2000 Niemann 2003). The aim of this kind of life cycle management is an ecological and economic optimization over the entire product life cycle. Therefore, all involved actors must be integrated into the life cycle phase development, production, use, and service, as well as recycling and reuse. 

The framework for total life cycle management is based on the ideas of the Viable System Model and the St. Galler concept of integrated management (Herrmann and Bergmann 2009 Herrmann 2010). The product life cycle phases are shown at the center of the framework — from product idea to disposal. Sustainable... 

Jorgensen, T. (2008). Towards more sustainable management systems through life cycle managment and integration. Journal of cleaner production 16, 1071-1080. 

Companies may use the calendar either as a stand-alone software solution or it may be integrated with the company-wide product data management (PDM) or product life-cycle management (PLM) solutions. In some systems there is a functionality to notify the responsible party with flagging when certain activities are not met according to the scheduled time. 

Implement total life cycle management for new and/or integrated systems... 

ARC White Paper, Siemens Offers a Comprehensive Product Portfolio for Safety Life-cycle Management, ARC Advisory Group, May 2009, http //w3.siemens.com/topics/mea/ en/safety-integrated/Documents/white-paper-process-safety-2009.pdf. 

Entities developing and commercializing nanotechnology products should consider "Product Stewardship" approaches integrating Life Cycle Assessment. These strategies may help developers identify and manage risks from the earliest stages of product conceptualization to disposal and/or recovery/reuse. 

Stage Gate SG2 forms the most important strategic milestone in the integrated life cycle becanse it determines the finther comse of the project. The developed design specification, the re-worked plans and the updated effort and cost estimates allow management to re-evaluate the project and to decide upon its future. If the decision is to continue the project, the activities of System Safety Assessment (SSA) and of system development are triggered. Those activities are monitored by project control. 

Because of their similar life cycles, habits, damage to corn, and apparent resistance to conventional corn rootworm insecticides, we could expect both the PSB and HBV to increase their densities and/or range throughout the Midwest much as the PSB has (9,12). These concerns are evident in the 1985 establishment of a multistate regional research effort entitled "Impact of integrated crop management practices on European corn borer and related stalk boring insects". 

This comprehensive approach allows for efficient integration between processes, different phases of product life cycle, and integration between different sites in the supply chain. This integration provides opportunity for efficiency in that process owners are integrated with each other s needs and expectations. Duplication of effort is avoided and efficiencies gained. Quality outputs from one process become reliable inputs into the next process. Management and leadership will have access and insight into compliance, infrastructure, and performance metrics of all processes on a comparable basis. This provides leadership the opportunity for risk-based resource allocation to appropriate areas of the enterprise. 

A consensus vision statement was drafted at the July 2003 ICH meeting with regard to the objective of the ICH in harmonizing the efforts of regulatory bodies to establish quahty systems approaches in their operations Develop a harmonized pharmaceutical quality system applicable across the life cycle of the product emphasizing an integrated approach to quality risk management and science. ... 

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