Candidate selection

The scheme has been marketed through company websites and invitation letters. Half of the mentors recruited for the program were internal to Ericsson and typically recommended by senior management. The other half, the external mentors, were recruited with help from the business school IMD - they supplied a range of individuals who committed to mentoring on a voluntary basis. In the recruitment of mentees, Boultwood received assistance from HR and line managers in other countries, who nominated candidates. Selection criteria for mentors included that they had to be ... 

Ganter B, Tugendreich S, Pearson Cl, Ayanoglu E, Baumhueter S, Bostian KA, et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. J Biotechnol 2005 119 219-44. 

Theil FP, Guentert TW, Haddad S, Poulin P. Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol Lett 2003 Feb 18 138(l-2) 29-49. Review. 

Rapid physicochemical profiling as an aid to drug candidate selection. In ... 

Chaubal, M. Application of drug delivery technologies in lead candidate selection and optimization. Drug Discov. Today 2004, 9, 603-609. 

The genesis of in silico oral bioavailability predictions can be traced back to Lip-inski s Rule of Five and others qualitative attempts to describe drug-like molecules [13-15]. These processes are useful primarily as a qualitative tool in the early stage library design and in the candidate selection. Despite its large number of falsepositive results, Lipinski s Rule of Five has come into wide use as a qualitative tool to help the chemist design bioavailable compounds. It was concluded that compounds are most likely to have poor absorption when the molecular weight is >500, the calculated octan-l-ol/water partition coefficient (c log P) is >5, the number of H-bond donors is >5, and the number of H-bond acceptors is >10. Computation of these properties is now available as an ADME (absorption, distribution, metabolism, excretion) screen in commercial software such as Tsar (from Accelrys). The rule-of-5 should be seen as a qualitative, rather than quantitative, predictor of absorption and permeability [16, 17]. 

CS, preclinical candidate selection I I II I, first time in human PI, phase 1 P2, phase 2 POC, proof of concept. 

Lesko, L.J., Rowland, M., Peck, C.C., and Blaschke, T.F. (2000). Optimizing the science of drug development opportunities for better candidate selection and accelerated evaluation in humans, Pharmaceutical Research 17 1335-1344. 

Design of liquid enzyme products with built-in liquid detergent stabilization system 155 5.4 CANDIDATE SELECTION... 

Integrated Drug Product Development — From Lead Candidate Selection to Life-Cycle Management... 

High-throughput drug-like property profiling is increasingly used during lead identification and candidate selection. HTS pharmaceutical profiling may include ... 

Compound purity (or integrity testing) is important to ensure purity in the early stages because erroneous activity or toxicity results may be obtained by impure compounds, ft is initiated during hit identification and continued into lead and candidate selection. 

Once compounds enter the late lead selection or candidate selection phase, more in-depth physicochemical profiling is conducted. The extent of characterization may vary from company to company however, it likely includes ... 

Gibson, M., Pharmaceutical Preformulation and Formulation A Practical Guide from Candidate Selection to Commercial Dosage Form, CRC Press LLC, Leicestershire, 2004. 

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