Solution Software

A more serious limit to this implementation is due to the volume of the recycling pump and associated equipment such as flowmeters and pressure sensors. As the pump moves with respect to the zones, its volume leads to a dead volume dissymmetry, which can lead to a decrease extract and raffinate purities. This decrease can be significant for SMB with short columns and/or compounds with low retention. However, it can be easily overcome by using a shorter column or asynchronous shift of the inlets/outlets [54, 55]. This last solution is extremely efficient and does not induce extra costs because it is a purely software solution. 

Goldratt has outlined the necessary and sufficient conditions for a technology to confer a benefit [23]. To generate productivity from a new technology he advocates answering a set of questions about the technology. Let s use them in detail to examine software solutions in the pharmaceutical industry. Goldratt s questions are as follows ... 

Searching Google.com for e-clinical provides many vendors. Some of these are Oracle Clinical v4i from Oracle Corporation [34], DataLabsXC from DataLabs, Inc. [35], TrialMaster from OmniCommSystems [36], and Clin-Plus Data Management (CPDM) by DZS Software Solutions, Inc. [37]. 

There have been considerable efforts toward modeling ADME/Tox properties and the biophysical properties of molecules (see chapters 18-20, 22, 28), including numerous commercial software solutions. Simulations Plus (http //www.simulations-plus.com/) have developed GastroPlus, a product... 

To keep control of your SAS programs you should learn about and invest in version control software. There are many commercial and free (RCS or CVS) version control software solutions available that do an excellent job of maintaining the integrity of your SAS programs. You can also integrate your version control software solution into your SAS program editor. 

There are many software tools available to help with the acquisition, processing and interpretation of NMR data. Attempts have been made to automate the verification process and even perform full structural elucidations of unknown compounds. As you might guess from the complexity of the interpretation chapters, these software solutions are not foolproof It remains to be seen whether they ever will be good enough but there have certainly been some major steps forward in all of these areas. 

Best Practice Analysis characterize the management practices and software solutions that result in best-in-class performance. 

A number of software solutions still support this classical approach ... 

Domain or business models These describe the domain or business at hand, often independently of particular software solutions. It can include as-is and to-be models of the business. It is sometimes useful to analyze the as-is model, decide which aspects of it represent essential requirements, and abstract out an essential domain model that can then be refined to the envisaged to-be solution model. Domain models are reusable across multiple projects. 

Pattern 14.2, Make a Business Model. Understand the terms your clients are using before anything else capture business rules, behaviors, and constraints that are independent of software solutions. 

SuetaInability of software solutions for LIMS and data workflow... 

H. Nakashima, Y. Hirata, K. Jinno, P. Sandra, A. J.Rackstraw Proceedings of the 22nd International Symposium on Capillary Chromatography, Gifu, Japan, Naxos Software Solutions, M. Schaefer, Scriesheim, Germany, 1999. 

Integrated software solutions for project management and analysis of available proteomic information. 

We power the process of invention. Over 1,000 life science companies supercharge their discovery engines with MDL software solutions to generate fresh ideas and make breakthrough discoveries. 

The most cost-effective solution for a software project is to buy a good product that meets your needs off the shelf. Unfortunately this is not always possible. Vendor products are often too generic and require significant customization to be useful to your organization. Outsourcing is another way of buying software solutions, and they will be discussed in this chapter. 

II. Product Summaries BioByte provides a variety of software solutions to the drug discovery scientist that range from a chemically-oriented database system to a unified driver for ClogP/CMRprograms. 

Only those situations can be handled by software which are foreseen in the design phase and for which software solutions have been found and implemented. Since a substantial part of accidents (Wagenaar and Groeneweg, 1987) happen precisely because of unforeseen or impossible circumstances, the flexible human operator will have to be present in order to cope with these, even though he will have difficulties in doing so pre-sicely because of those same reasons,... 

Out-of-the-box HTS informatics software solutions with integrated functionality of all three operational components (HTS data, plate and sample tracking, chemical structures) include ActivityBase from IDBS, Assay Explorer from Symyx (former MDL), BioAssay Enterprise from CambridgeSoft, Accord Enterprise (Accelrys), Chemlnnovation (CBIS), and others. However, we recommend careful evaluation of functionality, usability, architecture, and availability of a published application programming interface (API) if the system is to be integrated with other informatics components. Because the commercial solutions have different strengths, one answer is to combine different components or build certain functionalities in-house. 

Manual maintenance of RTM documents can be labor intensive and error prone, so it is recommended that the availabihty of software solutions or CASE tools for managing traceability information be considered as an alternative. Spreadsheet applications are an obvious choice in simple cases. For more complex document sets, a more sophisticated automated solution is much more likely to be up to the job. 

Although it is no longer common practice to implement bespoke/custom software solutions when implementing LIMS, it may be necessary for software modules to be developed or modified to meet a specific business need. In such cases the new or modified module should be developed in accordance with a software development life cycle. 

Where an industry standard modular application is selected as a software solution, it may include functionality within the application that supports different business processes operated by other companies who use the same application. Unless this additional functionality can be disabled within the application, which is not always technically possible, there is a risk that this functionality may be accessed by end users even though the site has not validated this usage. This situation should be controlled by ensuring that all end users are trained in the specific functionality within the application that they are expected to use to support their business processes, and that this training should be supported by SOPs that clearly state that no alternative processes are to be undertaken. 

Table 7.1 Recently published software solutions for automated ligand-based de novo design.

AspenTech has developed and applied quantitative cost-benefit analysis for engineering systems, including applied thermodynamics. The analysis, provided by Aspen Value Process (AVP), is a collaborative process yielding multi-level, broad commitment for business process changes enabled by software solutions. A key outcome of AVP is the customers validation of the estimated value. The financial information is highly sensitive and consequently there are no published cases available. Here, we present the basic approach and give typical quantitative assessment results. One could either carry out an extrapolation of this analysis to assess the industry-wide benefits (as is done below), or, alternatively, carry out a series of these assessments with specific producers. 

Strategic and tactical consideration for how the pharmacy software solution matches up with the clinical information systems, Internet solutions, health resource planning, access management, decision support, home care, managed care, and infrastructure applications. 

These considerations are primarily enterprise-wide in scope. With integration being of primary importance to healthcare in general, it is still necessary to obtain best-of-class software solutions for specific pharmacy activities. Recommendations that will help select appropriate applications and technologies that are backed by reliable implementation, support, and services will be the focus of the remainder of this chapter. Refer to Tables 1 and 2 (used with permission from ComputerTalk) as you read this chapter. These figures contain an extensive evaluation of the current information systems market. 

Related to the difficulties associated with reproducibility, is the challenge presented by comparison of many—perhaps hundreds to tens of thousands of—complex spectra and the resulting data interpretation. Several groups have developed their own analytical and software solutions to this problem. Jarman et al. [33] and Bright et al. [29], for example, developed methods to automatically compare spectra of unknown bacteria with those of library entries to accomplish high-quality identifications. The recent emergence of bacteria as potential terror weapons will likely spur further efforts in the development... 

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