Instrument Malfunction

Air leaks. This causes erroneous reading at the instrument. To remedy, seal air leak. 

Improper adjustment. Proportioning band and reset should be adjusted to give smooth control. Damping must not be so great that sensitivity is lost. Consult manufacturer s manual for instrument adjustment procedures. 

If foaming is inherent to the solution, a suitable antifoam agent may be used. Selection of a suitable antifoam must include the effects upon the crystal habit and growth rate as well as the amount required, availability, and cost. 

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In continuous processes where automatic feedback control has been implemented, the feedback mechanism theoretically ensures that product quality is at or near the set point regardless of process disturbances. This, of course, requires that an appropriate manipulated variable has been identified for adjusting tne product quality. However, even under feedback control, there may be daily variations of product quahty because of disturbances or equipment or instrument malfunctions. These occurrences can be analyzed using the concepts of statistical quahty control. 

Equipment/instrumentation malfunction tliat can be a factor in tlie appearance of a hazard... 

A measurement technique such as titration is employed that provides a single result that, on repetition, scatters somewhat around the expected value. If the difference between expected and observed value is so large that a deviation must be suspected, and no other evidence such as gross operator error or instrument malfunction is available to reject this notion, a statistical test is applied. (Note under GMP, a deviant result may be rejected if and when there is sufficient documented evidence of such an error.)... 

The Inspect Disc File function is sometimes useful in diagnosing problems due to instrument malfunctions or inappropriate instrument settings. All functions that write files to the disc Include software write protection to guard against accidental erasure. 

There are two ways to approach this issue, and both should be investigated in any questionable measurement. First, it is often assumed that any absorption or other measurement that is three or four times larger than the noise is real. This is a good start. However, there are other more scientific approaches to this problem. If repeated measurements on different subsamples or aliquots produce the same absorption or measurement, with minor variations, then it is probably a real result and not noise. On the other hand, if, during repeated measurements, absorption features occur in exactly the same location and have exactly the same characteristics such as shape and area under the peak, then they are probably not due to the sample because some variation in measurement always occurs. This type of problem is usually a result of instrument malfunction and this must be investigated. 

Errors in the analytical laboratory are basically of two types determinate errors and indeterminate errors. Determinate errors, also called systematic errors, are errors that were known to have occurred, or at least were determined later to have occurred, in the course of the lab work. They may arise from avoidable sources, such as contamination, wrongly calibrated instruments, reagent impurities, instrumental malfunctions, poor sampling techniques, errors in calculations, etc. Results from laboratory work in which avoidable determinate errors are known to have occurred must be rejected or, if the error was a calculation error, recalculated. 

Capability for rapid, easy diagnosis and correction of instrument malfunctions. 

A high potential incident is an occurrence that under different circumstances might easily have resulted in a catastrophic loss. An example could involve the early discovery of an instrument malfunction (by a diligent operator) that might otherwise have resulted in a process upset and violent explosion. 

The baseline of the atomic peak can steadily increase its absorbance because of instrumental malfunction, drift, a sample constituent giving rise to proportional interferences or an atomisation problem. The general appearance is that the atomic peaks are stacked , but this arrangement is not related to the concentration of the analyte. Baseline correction is a general practice in atomic spectrometry to measure accurately the height or the total area under the peak. In multivariate analysis, the procedure is the same in order to start all atomic peaks in the same absorbance position, in general at zero scale. The most basic baseline correction is offset correction, in which a constant value is subtracted to all absorbances that define the atomic peak (Figure 4.10a). 

If the analyst cannot cite a definite physical reason for failure to include a specific sample measurement, such as evident instrument malfunction, sample container leakage, or sample loss on transfer or injection, then there is no justification for deleting a measurement from subsequent evaluation of a total sample series. If, on injection of a sample into the chromatograph, the operator believes that septum leak is evident, the resulting chromatogram should be marked immediately and never measured or included in the subsequent results. Conversely, if he cannot cite such a reason, the resulting chromatogram must be measured and included in the overall evaluation of the study. 

Instrument malfunction. Ensure automated stainer is programmed correctly and is running to manufacturer s specifications. Specification Sheet... 

Data Management. Data were invalidated for the following reasons obvious physical contamination of a sample, instrument malfunction, evidence of erroneous data entry, and outlying observations. 

A single instrument or mechanical failure. Pump failure, loss of flow, instrument malfunction, line rupture or leak, loss of cooling. 

In simulation mode, the performance of the process can be followed. Discrepancies between the model and the process may reveal instrumentation malfunction, problems of maintenance etc. Verified flow-sheet models can be used to... 

The inherent accuracy and precision of instruments have a profound influence on the quality of the results they produce. In addition, instrument malfunction is now recognized as a potential source of error, and one survey ascribed 18% of the errors detected as due to equipment (W17). Such errors are usually detected by quality control of the complete analysis, but identification of the cause is more difi cult and is often unsuccessful because of the lack of suitable methods of quality control of instruments. If these were applied as part of regular maintenance, errors would undoubtedly be identified more rapidly and before they significantly affected the analysis. 

Display of specimens currently being analyzed, tests ordered on each specimen, and expected times of completion Accumulation of sets of patient results Collation of results for patient-oriented printout Provide warning messages to alert operator to instrument malfunction, need for maintenance, or unusual clinical situation... 

ACAMS alarms must be verified to ensure that they are not a false positive due to an interferent species or instrument malfunction. This verification is done using a depot area air monitoring system (DAAMS) deployed near an ACAMS. DAAMS is a passive system that draws an air stream through a sorbent tube. The tubes are collected and replaced periodically if there are no ACAMS alarms or shortly after an alarm occurs. They are transported to a laboratory and thermally desorbed onto a sample tube and analyzed on a laboratory scale GC/FPD system. Without confirmation by the more sensitive... 

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