Inhibition of angiogenesis

Calcineuiin signaling and NFAT also play an important role in the regulation of vascular development, balancing activation and inhibition of angiogenesis. NFAT3 and... 

FOTSIS T, PEPPER M S, MONTESANO R, AKTAS E, BREIT S, SCHWEIGERER L, RASKU S, WAHALA K and ADLERCREUTZ H (1998) Phytoestiogeus and inhibition of angiogenesis. .Sad/ierei Clin Endocrinol Metab. 12 (4) 649-66. 

Maione TE, Gray GS, Petro J, et al. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 1990 247(4938) 77-79. 

Kronenwett R, Graf T, Nedbal W et al. Inhibition of angiogenesis in vitro by alphav integrin directed antisense oligonucleotides. Cancer Gene Ther. 2002 9 587-596. 

VEGF binds to endothelial receptors Fit-1 and Flk-1 to activate a signal transduction cascade (Fig. 4). Neutralizing antibodies to Flk-1 inhibit angiogenesis (21). This inhibition of angiogenesis is most effective in glioblastoma xenographs and also reduces tumor... 

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness. The response to penicillamine is usually delayed (4-12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug s efficacy is limited thus, penicillamine is seldom used to treat rheumatoid arthritis. The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication. 

From these results, it seems likely that the antitumor activity of ergosterol might be due to direct inhibition of angiogenesis induced by solid tumors. 

Mantena SK, Meeran SM, Elmets CA, Katiyar SK. 2005. Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr 135 2871-2877. 

Verheul, H.M. and H.M. Pinedo. 2005. Inhibition of angiogenesis in cancer patients. Expert Opin. Emerg. Drugs 10 403-412. 

Vermette P, Meagher L, Gagnon E et al (2002) Immobilized liposome layers for drug delivery applications inhibition of angiogenesis. J Control Release 80 179-195... 

Piossek, C., Thierauch, K.-H., Schneider-Mergener, J., et al. (2003) Potent inhibition of angiogenesis by D, L-peptides derived from vascular endothelial growth factor receptor 2. Thromb Haemost. 90, 501-510. 

Compound efficacy has been correlated with the inhibition of angiogenesis in a variety of assays (endothelial capillary tube formation, aortic ring assay, chorioallantoic membrane assay, real-time tumor blood flow and PO2 measurements, tumor blood vessel density, and tumor hypoxic and apoptotic fractions) [35]. 

Masso-Welch, P.A., Zangani, D., Ip, C. et al., Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid, Cancer Res., 62, 4383-9, 2002. 

Activated VEGFR1 alone, however, has relatively weak tyrosine kinase activity and may be insufficient to stimulate endothelial cell proliferation [20]. On the other hand, inhibition of angiogenesis by factors such as pigment epithelium-derived factor (PEDF) is associated with reduced VEGF-induced phosphorylation of VEGFR1 [23],... 

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