Inducing labor

The first SPRM to reach the advanced stage of clinical development for treatment of endometriosis and uterine fibroids, asoprisnil, is expected to receive FDA approval this year. The therapeutic effect of asoprisnil stems from its PR antagonist/ antiproliferative activity in the endometrium and breast. Unlike classical PR antagonists however, this compound does not induce labor in animal models of pregnancy and parturition. Recent structural studies... 

Methylergonovine is contraindicated in patients with a known hypersensitivity to the drug, hypertension, and preeclampsia and should not be used to induce labor (Pregnancy Category C). Methylergonovine is used cautiously in patients with renal or hepatic impairment. When methylergonovine is administered concurrently with vasopressors or to patients who are heavy cigarette smokers, excessive vasoconstriction may occur. 

Oxytocin is contraindicated in patients with known hypersensitivity to the drug, cephalopelvic disproportion, unfavorable fetal position or presentation, in obstetric emergencies, situations of fetal distress when delivery is not imminent, severe toxemia (preeclampsia, eclampsia), hypertonic uterus, during pregnancy (intranasal administration), when there is total placenta previa, or to induce labor when vaginal delivery is contraindicated. Oxytocin is not expected to be a risk to the fetus when administered as indicated. When oxytocin is administered with vasopressors, severe hypertension may occur. 

OXYTOCIN The patient receiving oxytocin to induce labor may have concern over the use of the drug to produce contractions. When given to induce or stimulate contractions, oxytocin may only be given intravenously (IV). The nurse explains the purpose of the IV infusion and the expected results to the patient. Because the patient receiving oxytocin must be closely supervised, the nurse spends time with the patient and offers encouragement and reassurance to help reduce anxiety. 

Judith Watson, aged 28 years, is admitted to the obstetric unit and is to receive oxytocin to induce labor. This is her first child, and she is extremely anxious. Analyze what information would be necessary for her to receive from the nurse before the administration of oxytocin. What assessments would be important for the nurse to make during treatment with oxytocin ... 

Oxytocin, a hormone composed of nine amino acids, which induces labor by stimulating contraction of uterine muscles... 

The eicosanoids have a broad spectrum of physiological activities and these are elicited at very low concentrations, 10 M or less. They mediate the inflammatory response, produce pain and fever, regulate blood pressure, initiate blood clotting, induce labor, and regulate the sleep/wake cycle. 

Therapeutic applications. PG derivatives are used to induce labor or to interrupt gestation (p. 126) in the therapy of peptic ulcer (p. 168). and in peripheral arterial disease. 

Uterine rupture has been reported when misoprostol was administered intravaginally in pregnant women to induce labor or to induce abortion beyond the first trimester of pregnancy. 

Oxytocin is generally considered to be the drug of choice for inducing labor at term. In combination with amniotomy, oxytocin is highly successful in inducing and augmenting labor. When given oxytocin, approximately 80% of patients with documented labor disor-... 

L Which of the following is the drug of choice for inducing labor ... 

B. Clinical evidence has shown that the use of this agent has saved many women from surgery by controlling postpartum hemorrhage. It can also induce labor but is not the drug of choice. It will induce... 

Answer In this case, the decision to induce labor is appropriate. In caring for patients, physicians must decide who are appropriate patients for labor induction. The median length of human pregnancy is 40 weeks (when using the woman s menstrual period to date the pregnancy). Pregnancy is considered to be full-term from the 37 0/7 weeks to 41 6/7 weeks. 

Cuba. Hot water extract of the seed is taken orally by males as an anaphrodisiac k Haiti. Decoction of the grilled fruit and leaf is taken orally for anemia, edema, asthenia, and rage. The fruit is taken orally for hepatitis and liver troubles. The soaked fruit is used externally for nervous shock. For headache, the leaf decoction is taken orally or the leaf is applied to the head h Mexico, The leaves are made into a poultice and used to treat fever . Hot water extract of the roasted seed is taken orally by nursing mothers to increase milk production h Nicaragua. Leaves are used externally for headache, and the hot water extract is taken orally for stomach pain . Decoction of the seed is taken orally for fever and used externally for cuts and hemorrhage L Peru. Hot water extract of the dried fruit is taken orally as a stimulant for sleepiness and drunkenness h Infusion of the leaf is taken orally to induce labor, and the hot water extract is taken orally as an antitus-sive in flu and lung ailments . 

Theoretically, PGE2 and PGF2K should be superior to oxytocin for inducing labor in women with preeclampsia-eclampsia or cardiac and renal diseases because, unlike oxytocin, they have no antidiuretic effect. In addition, PGE2 has natriuretic effects. However, the clinical benefits of these effects have not been documented. In cases of intrauterine fetal death, the prostaglandins alone or with oxytocin seem to cause delivery effectively. 

Oxytocin is used to induce labor for conditions requiring early vaginal delivery such as Rh problems, maternal diabetes, preeclampsia, or ruptured membranes. It is also used to augment abnormal labor that is protracted or displays an arrest disorder. Oxytocin has several uses in the immediate postpartum period, including the control of uterine hemorrhage after vaginal or cesarean delivery. It is sometimes used during second-trimester abortions. 

Achyranthes asperia L. var. indica L. Tu Niu Teng (Prickly chaff flower) (seed) Beta-carotene, thiamine, riboflavin, niacin, saponins, ascorbic acid, protein.50 Antispasmodic, diuretic, induce labor, antifertility, antiinflammatory. 

Scopalia dulcis L. Tian Zhu Cao (whole plant) Amellin, dulciol, hexacosanol, mannitol, beta-sitosterol, mannitol, tannins, hexacosanol, salicylic acid, scopanol, dulcilone, tetulinic acid, ifflaionic acid.50-86 A cough remedy, induce labor, used as an opium substitute. Therapeutic action in diabetes in some reports. 

A number of medical uses of prostaglandins have been discovered and more will probably be developed. While prostaglandins may be required for conception, small amounts of PGE2 or PGF2a induce abortion. PGF2a is also used to induce labor. Prostaglandins are widely employed to control breeding of farm animals, to synchronize their estrus cycles, and to improve the efficiency of artificial insemination.307... 

Uterine rupture also occurred in another three women (ages not stated) after misoprostol (dosages not stated) was used to induce labor. One underwent cesarean section because labor did not progress. During the procedure, the fetal hand and head were outside the uterine cavity (maternal and fetal outcome not stated). 

There are only two methods of inducing elevated Oxytocin levels. First would be a trip to the closet with ones lover just before stepping on stage. (Yes, it is actually done) The second, is an exogenous source. Oxytocin is utilized to induce labor in farm animals, and is available in a powder form at many feed stores. Since the hormone is orally active, the rest should seem obvious. (But is not suggested )... 

A doctor or a midwife can strip your membranes, which is a technique used to induce labor by placing a finger within the cervix and running it around the inside to separate the membranes from the lower uterine area. 

---