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In humans determination

C. Joqueviel, R. Martino, V. Gilard, M. Malet-Martino, P. Canal, U. Niemeyer, Urinary Excretion of Cyclophosphamide in Humans, Determined by Phosphorus-31 NMR Spectroscopy , Drug Metab. Dispos. 1998, 26, 418 - 428. [Pg.757]

Kuhl, D.E., ct al. Epileptic Patterns of Local Cerebral Metabolism and Perfusion in Human Determined by Emission Computed Tomography. Ann Neurol., 348 (August 1980). [Pg.1763]

Joqueviel, C., Martini, R., Gilard, V., Malet-Martino, M., Canal, P., and Niemeyer, U., Urinary excretion of cyclophosphamide in humans, determined by phosphorus-31 nuclear magnetic resonance spectroscopy, Drug Metab. Disposition, 26, 418-428, 1998. [Pg.234]

L Duntas, et al. Pharmacokinetic profiles of intravenously, nasally and orally applied thyroliberin in humans—Determination by radioimmunoassay and fast protein liquid chromatography. Acta Endocrinol 114 81, 1987. [Pg.323]

Abrahamsson, B., K. Lindstrom, L. Nyberg, A. Pettersson, M. Sunzel, A-L. Ungell, and W. Mansson. 1997. Regional absorption of metoprolol in humans determined by a new method suitable for studies in the whole gastro-intestinal (GI) tract. Proceedings of the controlled Release Society. 24 359-360. [Pg.143]

The Kinetics of Ingested 222Rn in Humans Determined from Measurements with 133Xe... [Pg.145]

In Phase I, dmg trials, the dmg is given to a small number of healthy volunteers to determine safe dosage levels. The purpose is to document the dose level at which signs of toxicity first appear in humans, determine a safe tolerated dose, and determine the pharmacokinetics of the dmg. Pharmacokinetics will be discussed in Chapter 2. Volunteers who give consent to participate are monitored closely during this phase. Permission must be obtained from the FDA to conduct Phase I clinical trials. [Pg.33]

Because iCg values for competitive antagonists represent tme dissociation constants, these make possible quantitative interpretations of SARs. Significant use also has been made of iCg values in the quantitative comparison of receptors to determine whether receptors that respond to the same agonists are identical or whether responses produced by different agonists are initiated at the same receptors (44,46). Thus, beta-adrenoceptors in human and guinea pig preparations can be direcdy compared and selective and antagonists quantitated (Table 3). [Pg.276]

The demonstration that injected or force-fed neonatal rodents given extremely high doses of MSG showed evidence of brain lesions, has led to much additional research to determine any possible link between neurotoxicity and human use of MSG (33). However, no evidence from animal tests indicates that MSG in the diet causes brain damage in humans (34). [Pg.305]

As a result a new approaehes in DCP-ai e atomie-emission speetrometry were applied for Ca, Mg, Cu, Zn, Fe and P determination in blood semm and Ca, Mg, Cu, Zn, Fe, P, Mn, Pb, Cd, Sn, Sr et al. - in human and animals hair with relative standai d deviation (RSD) about 10-20 %. The aeeuraey eontrol has been realized by a eomparison of data produeed with the results of independent methods (atomie-absorption speetrometry and inverse voltammetry). [Pg.226]

Hyphenation of HPLC with NMR combines the power of sepai ation with a maximum of stiaictural information by NMR. HPLC-NMR has been used in the detection and identification of diaig metabolites in human urine since 1992. The rapid and unambiguous determination of the major metabolites of diaigs without any pretreatment of the investigated fluid represents the main advantage of this approach. Moreover the method is non-destmctive and without the need to use radiolabelled compounds. [Pg.342]

DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING RP-LC WITH ELECTROCHEMICAL DETECTION... [Pg.395]

A selective, sensitive and stability indicating reversed phase-HPLC method was developed for the determination of clarithromycin antibiotic in human plasma. [Pg.395]

The analysis of the consequences of nuclear accidents began with physical concepts of core melt, discussed the mathematical and code models of radionuclide release and transport within the plant to its release into the environment, models for atmospheric transport and the calculation of health effects in humans. After the probabilities and consequences of the accidents have been determined, they must be assembled and the results studied and presented to convey the meanings. [Pg.331]

Conditions of health and age play an important role in human performance. Job demands will determine the general fitness and age of the workers to be employed for a particular job. Recent illness can affect the level of alertness, the required concentration on the job, and the capability to cope with high workload. [Pg.141]

Hazard identification is defined as tlie process of determining whetlier human exposure to an agent could cause an increase in the incidence of a health condition (cancer, birtli defect, etc.) or whetlier exposure to nonliumans, such as fish, birds, and otlier fonns of wildlife, could cause adverse effects. Hazard identification cliaracterizes tlie liazard in terms of tlie agent and dose of the agent. Since tliere are few hazardous chemicals or hazardous agents for wliich definitive exposure data in humans exists, tlie identification of health hazards is often characterized by the effects of health hazards on laboratory test animals or other test systems. ... [Pg.299]

Comment When using data for LOELs, LOAELs, NOELs, or NOAELs, it is important to be aware of their limitations. As discussed in the chapter, statistical uncertainty exists in the determination of these parameters due to the limited number of animals used in the studies to determine the values. However, any toxic effect might be used for the NOAEL and LOAEL so long as it is the most sensitive toxic effect and considered like it to occur in humans. [Pg.343]

A stereoselective determination of enantiomers of 5, its A -oxide and N-desmethyl metabolites in human urine was developed by capillary electrophoresis using laser-induced fluorescence detection and sulfonated /1-cyclodextrin in the running buffer (01JC(B)169). [Pg.266]


See other pages where In humans determination is mentioned: [Pg.669]    [Pg.269]    [Pg.40]    [Pg.139]    [Pg.669]    [Pg.269]    [Pg.40]    [Pg.139]    [Pg.101]    [Pg.457]    [Pg.2]    [Pg.307]    [Pg.31]    [Pg.211]    [Pg.213]    [Pg.374]    [Pg.246]    [Pg.284]    [Pg.36]    [Pg.45]    [Pg.557]    [Pg.23]    [Pg.89]    [Pg.301]    [Pg.106]    [Pg.300]    [Pg.316]    [Pg.289]    [Pg.300]    [Pg.322]    [Pg.349]    [Pg.196]    [Pg.292]    [Pg.299]    [Pg.299]    [Pg.300]    [Pg.17]   
See also in sourсe #XX -- [ Pg.44 , Pg.398 , Pg.399 , Pg.400 , Pg.401 , Pg.402 , Pg.403 , Pg.404 , Pg.405 , Pg.406 , Pg.407 , Pg.408 ]




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