Immunosuppressive agents cyclophosphamide

Activities of 748 (FIAC), 758 (FMAU), and related compounds against several viruses were compared, " and the combined effects of 748 (FIAC) and 758 (FMAU) with other antiviral drugs, or with cyclophosphamide (for FMAU), an immunosuppressive agent, were examined. 

The treatment of collagen disease is based on immunosuppressive therapies. Immunosuppressive agents, such as corticosteroids, are widely used. In addition, cytotoxic agents (azathioprine, cyclophosphamide, and methotrexate) have also been administered. 

Initially, the immunosuppressive agents, such as cyclophosphamide (32), azathioprine, and methotrexate, were developed to inhibit malignant cell proliferation. The immunosuppressant activity was discovered later and these agents were then applied to treat autoimmune diseases, where patients did not respond to high doses of steroids (51). The potential side effects associated with these agents have encouraged the search for unique immunosuppressants having more acceptable safety and efficacy profiles (62). Future approaches need to incorporate early treatment with immunotherapy... 

Cyclophosphamide (Cytoxan and Endoxan) is used in the treatment of Hodgkin s disease, lymphosarcoma, and other lymphomas. It is employed as a secondary drug in patients with acute leukemia and in combination with doxorubicin in women with breast cancer. A drug combination effective in the treatment of breast cancer is cyclophosphamide, methotrexate, fluorouracil, and prednisone (CMFP). Cyclophosphamide is also an immunosuppressive agent. The toxicity of cyclophosphamide causes alopecia, bone marrow depression, nausea and vomiting, and hemorrhagic cystitis. 

As an alkylating agent, cyclophosphamide (Cytoxan) and its active metabolites destroy the rapidly proliferating lymphocytes and, hence, are potent immunosuppressive agents. Those metabolites that are devoid of alkylating properties also lack an immunosuppressive capability. Because the... 

Therapy for SEE is both complex and, in many instances, disappointing for both patient and practitioner. Management of the systemic signs and symptoms may not improve the ocular manifestations of the disease. The most common therapy for the arthritic and cardiac complications is NSAID use. Hydroxychloroquine and chloroquine are particularly effective in treating the discoid rash associated with the disease. In some cases oral steroids are used either alone or in combination with other immunosuppressive agents. Methotrexate can effectively reduce the need for systemic steroids in the treatment of mild to moderate SEE. Cyclophosphamide and... 

Cytotoxic agents destroy immimologically competent cells. Azathioprine, a prodrug for the purine antagonist mercaptopurine, is used in autoimmune disease because it provides enhanced immunosuppressive activity. Cyclophosphamide is a second choice. Bone marrow is depressed as is to be expected. 

Cyclophosphamide is used in human medicine as an antineoplastic (anticancer) agent in a variety of applications. Cyclophosphamide is a potent immunosuppressive agent and is used to prevent rejection episodes following renal, hepatic, and cardiac transplantation and in non-neoplastic disorders in which... 

NSC 109724 Asta 4942 Ifex Mitoxana and many other names) is related to cyclophosphamide, and also is an (alkylating) cytotoxic ANTICANCER and immunosuppressant AGENT. It works by interfering with cellular DNA and so inhibits cell replication. It is particularly used for testicular cancer, and is routinely used simultaneously with mesna (which reduces the urothelial toxicity), i-inositol myo-inositol. 

Glucocorticoids are often used in conjunction with other immunosuppressive agents such as cyclophosphamide arid methotrexate, which offer better long-term control than steroids alone. 

ALKYLATING AGENTS Cyclophosphamide (cytoxan, neosar) is an effective cytotoxic and immunosuppressive agent. 

ANIMAL EXPERIMENTS ANTIBODY FORMATION/DRUG EFF CYCLOPHOSPHAMIDE/THER USE ENGLISH ABSTRACT HYPERSENSITIVITY HYPERSENSITIVITY DELAYE/DRUG THY IMMUNIZATION IMMUNOSUPPRESSION IMMUNOSUPPRESSIVE AGENTS/THER USE MALE RATS SKIN TESTS TOXlNS/PHARMACO... 

The clinical course of chronic ILD is almost always slowly progressive, with stabilization over years (293,315). There is a paucity of data on the efficacy of corticosteroids, and immunosuppressive or cytotoxic agents. In one series, 9 of 14 patients responded to four weeks or more of corticosteroid therapy, but follow-up was short (293). The choice of immunosuppressive agent is uncertain, with cyclophosphamide often used in severe or progressive disease. 

Besides being used as an alkylating agent in cancer chemotherapy, cyclophosphamide is a unique drug when used as an immunosuppressant. First, it is the most powerful of all such drugs. Second, it kills proliferating cells, and evidently alkylates a certain region of... 

The following drug classes may have a potential drug interaction with nevirapine Antiarrhythmics, anticonvulsants, antifungals, calcium channel blockers, cancer chemotherapy (cyclophosphamide), ergot alkaloids, immunosuppressants, motility agents, opiate agonists. 

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