Immunological lipid

Lipoproteins (from human plasma). Individual human plasma lipid peaks were removed from plasma by ultracentrifugation, then separated and purified by agarose-column chromatography. Fractions were characterised immunologically, chemically, electrophoretically and by electron microscopy. [Rudel et al. Biochem J 13 89 1974.]... 

P. Sirois, M. Harczy, C. Robidoux, P. Borgeat and P. Braquet, in Lipid Mediators in Immunology of Burn and Sepsis, eds. M. Paubert-Braquet, P. Braquet, R. Demling, R. Fletcher and M. Foegh (Plenum Press, New York, 1987) pp. 187-196. 

A sophisticated respiratory host defence system has evolved to clear airborne particles and potential pathogens in inspired air [106, 143], The system comprises mechanical (i.e. air filtration, cough, sneezing and mucociliary clearance), chemical (antioxidants, antiproteases and surfactant lipids) and immunological defence mechanisms and is tightly regulated to minimise inflammatory reactions [92, 143],... 

The liposome lipid composition was varied in order to get (i) a high immunological response, (ii) to increase the dose, and (iii) to increase the stability of the formulation. A complete list of all investigated liposome formulations is given in Table 1. Liposomes were made with or without active ingredients. 

Methods for Determining Biomarkers of Exposure and Effect. Covalent adducts between reactive carbon tetrachloride metabolites (e.g., the trichloromethyl radical) and cellular proteins, lipids and nucleic acids are known to occur, but at present these can only be measured using radiolabeled carbon tetrachloride. Development of immunological or other methods to detect such adducts in humans exposed to carbon tetrachloride could be of value in estimating past exposures to carbon tetrachloride. 

CN187 Sadeghi, S., F. A. Wallace, and P. C. Calder. Dietary lipids modify the cytokine response to bacterial lipo-polysaccharide in mice. Immunology 1999 96(3) 404-410. 

In most cases, the small amount of newly synthesized glycosphingo-lipids can only be identified by the analysis of sugar composition, immunological activity, or t.l.c. mobility. These methods, however, cannot unequivocally distinguish the positional isomers. The highly... 

LPS immunotherapy was the first immunotherapy for cancers assayed in patients in spite of its toxicity. The standardisation of animal models of cancer, the discovery of the LPS composition and of lipid A activity, the discovery of lipid A structure leading to its chemical synthesis, and the synthesis of lipid A derivatives far less toxic than the natural lipids A, restarted research in this field. At the same time, advances in immunology allowed a better understanding of the mechanisms of action of LPS and lipids A in whole organisms. 

Reactive metabolites can react with important macromolecules including enzymes, DNA, or lipids. As indicated in Figure 4.72, this could lead to necrosis, an immunological reaction, a mutation, or cancer. 

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