Lipids nature

The Wassermann substance17 is prepared by extracting various animal organs, particularly beef heart, with alcohol, and its lipidal nature was early recognized. Pangborn174 described the preparation of a new phospholipid termed cardiolipin from beef heart and claimed that it was the essential constituent of the Wassermann substance. On hydrolysis it gave a fatty acid and a phosphorylated polysaccharide. In a later communication17 however, the carbohydrate constituent is stated... 

Much of the data produced in studies such as this has measured the partitioning of drugs into whole brain from blood or plasma. The importance of lipophilicity in brain distribution has therefore been highlighted in many reviews [3,4], however the majority of these have concentrated on total drug concentrations which, given the lipid nature of brain tissue, over-emphasizes the accumulation of lipophilic drugs. 

The lipid nature of the myelin sheath makes it water- and ion-imper-meant, and hence insulates the neuron to permit transfer or propagation of the electrical impulse. 

Maslov, M.A., Syicheva, E.V., Morozova, N.G. and Serebrennikova, G.A. (2000) Cationic amphiphiles of both lipid and non lipid nature in gene therapy. Russian Chem. Bull., 49, 385—401. 

Ambles, A., Colina-Tejada, A., Jambu, P., Lemee, L., and Parlanti, E. (1998). Experimental leaching of podzol soil lipids. Nature and biological origin of water soluble components. Agrochimica 42,158-171. 

Similarly, the pulp and the seed of olives (Olea europaea) were extensively analyzed (48). Olives are constituted of a complex matrix for proteo-mics studies due to their lipidic nature and the large amount of interfering compounds from where the extraction of proteins is difficult (49).This fruit is used for the extraction of oils and as food ingredient in the Mediterranean diet. The olive pulp protein extraction was performed by freezing 5 g of olive... 

Lipids Natural fats and oils Fractionated fats Mono- and diglycerides Phospholipids Glycolipids Waxes—beeswax, camauba wax... 

Goldsmith, L. A. and Baden, H. P. (1970). Uniquely oriented epidermal lipid. Nature (London) 225 1052. 

Spiegel S, Milstien S. Sphingosine-1-phosphate an enigmatic signalling lipid. Nature Rev. Molec. Cell Biol. 2003 4 397-407. 

Small molecule carbohydrates, lipids, natural products, drugs, drug-like molecules synthesis platform, ligand discovery, antibody binding screens, enzymatic assays, phenotypic cell-based screens, diagnostics, target deconvolution 12, 14-16, 21, 22, 25-32, 39, 40, 43, 44, 46, 48, 53, 55-65, 78... 

Anderson found that a substance of lipid nature was associated with the skeletal material of acid-fast bacilli. This lipid was not removed by neutral organic solvents but could be extracted with an ethereal or chloroform solution of hydrogen chloride. Saponification of these firmly-bound lipids yielded a polysaccharide having properties similar to those of the polysaccharide obtained from the purified wax. Phthiocerol was not detected. The polysaccharide was shown to contain... 

When it was used with cyclodextrin, the effectiveness of thimerosal was reduced however, this was related to the lipid nature of the other ingredients in the preparation. ... 

Vesely and Jakes (13) pointed out that the definition for lipides adopted in 1923 was not sufficiently precise. It included, among lipides, the fats formed of mixtures of esters and nonlipidic substances (free fatty acids, steroids, carotenoids, hydrocarbons) on the other hand, certain essential oils formed mainly of esters might be considered lipides. Vesely and Jakes advocated a more precise and concise definition for lipides natural esters nonvolatile with steam and possessing no aromatic ring in their molecule. ... 

L. Sternberg (1988) D/H ratios of environmental water recorded by D/H ratios of plant lipids. Nature 222, 59-61... 

G.R. Harvey, D.A. Boran, S.R. Piotrowicz, C.P. Weisel (1984). Synthesis of marine humic substances from unsaturated lipids. Nature, 309,244-246. 

Sternberg LdSL, DeNiro MJ, Ajie HO (1986) Isotopic relatiortships between saporriliable hpids and cellulose nitrate prepared from red, brown and green algae. Planta 169 320-324 Sternberg LdSL (1988) D/H ratios of environmental water recorded by D/H ratios of plant lipids. Nature 333 59-61... 

Free radical formation is associated with the normal natural metabolism of aerobic cells. The oxygen consumption inherent to cell growth leads to the generation of a series of free radicals. The interaction of these species with molecules of a lipid nature produces new species such as hydroperoxides and different kinds of peroxides [135, 136], This group of radicals (superoxide, hydroxyl, and lipoid peroxides) may interact with biological systems in a cytotoxic manner. In this respect, it has been shown to posses an important antioxidant activity towards these radicals, which is mainly based on the properties of the hydroxyphenolic groups and the structural relations between the different parts of the chemical structure. Together with an ability to capture electrons, these... 

The activity of QACs against viruses may depend on both the affinity of the QAC for the proteinaceous coat and the lipid nature of the viral envelope. QACs are quite active against lipophilic viruses such as HIV, influenza, and herpes simplex 1 2. However, their activity is lower against nonlipophilic viruses such as adenovirus or parvovirus [21]. 

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