Human normal immunoglobulin

Histaglobulin is a lyophilised preparation of histamine (as histamine dihydrochloride) coupled with human normal immunoglobulin. 

Human normal immunoglobulins hormone also [760] HPLC [767] somatropin for injection [918] ... 

Human normal immunoglobulin (HNIG) is prepared from screened, human plasma. The antibody fraction is extensively purified and contains immunoglobulins in glycine. Some products may contain sorbitol (refer to product information). HNIG is also used to treat possible infections as it contains antibodies to infectious pathogens against which the donors have been immunised. 

Normal immunoglobulin Human Specificities against variety of infectious and other biological agents prevalent in general population... 

Tourville DR, Adler RH, Bienenstock J, Tomasi TB, Jr. The human secretory immunoglobulin system immunohistoligical localization of gamma A, secretory piece, and lactoferrin in normal human tissues. / Exp Med 1969 129(2) 411-29. 

Bouvet JP, Pires R, Quan CP Protein Fv (Fv fragment binding protein) a mucosal human superantigen reacting with normal immunoglobulins in Zouali M (ed) Human B Cell Superantigens. Austin, RG Landes Company, 1996, pp 179-188. 

In this chapter we will discuss immunoglobulins of the IgG class, which is the major type of immunoglobulin in normal human serum, and which has the simplest structure. Each chain of an IgG molecule is divided into domains of about 110 amino acid residues. The light chains have two such domains, and the heavy chains have four. 

IgG The major immunoglobulin in human serum. There are four subclasses of IgG IgGl, IgG2, IgG3 and IgG4, but this number varies in different species. All are able to cross the placenta, and the first three subclasses fix complement by the classical pathway. The molecular mass of human IgG is 150 kDa and the normal serum concentration in man is 16 mg ml-1. 

Particles are most efficiently phagocytized when they are opsonized with complement components or immunoglobulins. This is accomplished by incubating the particles with autologous or normal human pooled serum, or with specific antibodies that recognize antigens on the particle surface. 

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