Nodular lymphocyte predominant Hodgkin

Nodular lymphocyte-predominant Hodgkin s lymphoma Classical Hodgkin s lymphoma... 

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)... 

M8. Marafioti, T., Hummel, M., Anagnostopoulos, I., Foss, H. D., Falini, B., Delsol, G., Isaacson, P. G., Pileri, S., and Stein, H., Origin of nodular lymphocyte-predominant Hodgkin s disease from a clonal expansion of highly mutated germinal-center B cells. N. Engl. J. Med. 337, 453— 458 (1997). 

Nil. Nguyen, P. L., Ferry, J. A., and Harris, N. L., Progressive transformation of germinal centers and nodular lymphocyte predominance Hodgkin s disease A comparative immunohistochemi cal study. Am. J. Surg. Pathol. 23, 27-33 (1999). 

Schmid, C., Sargent, C., and Isaacson, P. G., L and H cells of nodular lymphocyte predominant Hodgkin s disease show immunoglobulin light-chain restriction. Am. J. Pathol. 139,1281-1289 (1991). 

NLPHD nodular lymphocyte-predominant Hodgkin s disease... 

Hodgkin lymphoma (HL) is widely accepted to be a malignant clonal proliferation of B lymphocytes or, less often, T lymphocytes surrounded by variable numbers of inflammatory cells and fibrosis. The two major histologic types are classical Hodgkin lymphoma (CHL) and nodular lymphocyte predominance Hodgkin lymphoma (NLPHL). Classical Hodgkin lymphoma is further subdivided into four subtypes ... 

FIGURE 5.2 Nodular lymphocyte predominance Hodgkin lymphoma. (A) Low magnification showing nodular pattern. (B) Popcorn variants of Hodgkin/Reed-Sternberg cells. 

FIGURE 5.8 Leu7+ (CD57+) T lymphocytes surrounding Hodgkin/ Reed-Sternberg cells in nodular lymphocyte predominance Hodgkin lymphoma. 

Mason DY, Banks PM, Chan J, et al. Nodular lymphocyte predominance Hodgkin s disease. A distinct dinicopathological entity. Am J Surg Pathol. 1994 18 526-530. 

Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of nodular lymphocyte-predominant Hodgkin s disease from a clonal expansion of highly mutated germinal-center B cells. NEngl JMed. 1997 337 453-458. 

Prakash S, Fountaine T, Raffeld M, et al. IgD positive L H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. Am J Surg Pathol. 2006 30 585-592. 

Kamel OW, Gelb AB, Shibuya RB, et al. Leu 7 (GD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin s disease from nodular sclerosing Hodgkin s disease, T-cell-rich B-cell lymphoma and follicular lymphoma. Am J Pathol. 1993 142(2) 541-546. 

Menestrina F, Chilosi M, Scarpa A. Nodular lymphocyte predominant Hodgkin s disease and anaplastic large cell (CD30+) lymphoma Distinct entities or nonspecific patterns Semin Diagn Pathol. 1995 12 256-269. 

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