Immune thrombocytopenia

Aster, R.H., Drug-induced immune thrombocytopenia An overview of pathogenesis, Semin. Hematol., 36 (Suppl 1), 2, 1999. 

Bougie DW, Birenbaum J, Rasmussen M, Poncz M, Aster RH. (2008) Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. Blood 113 1105-1111. 

Fujisawa, K., Tani, P, and McMillan, R., Platelet-associated antibody to glycoprotein llb/Illa from chronic immune thrombocytopenia purpura patients often binds to divalent cation-dependent antigens. Blood l, 1284-1289 (1993). 

Hypersensitivity is most frequently manifested by pruritus and skin rashes. Severe drug induced immune thrombocytopenia can occur. Hemolysis may occur in patients with G6PD deficiency. 

Ueda, D., Sato, T., and Hatakeyama, N. (1998) Carbamazepine-induced immune thrombocytopenia in a 12-year-old female. Acta Haematol 100 104-10S. 

Teeling JL, Jansen-Hendriks T, Kuijpers TW, de Haas M, van De Winkel JG, Hack CE, Bleeker WK. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers studies in experimental immune thrombocytopenia. Blood 2001 98 1095-9. 

Sugiyama T, Okuma M, Ushikubi F, Sensaki S, Kanaji K, Uchino H A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and auto-immune thrombocytopenia. Blood 69 1712-1720,1987... 

Lanng Nielsen J, Dahl R, Kissmeyer-Nielsen F. Immune thrombocytopenia due to antazoline (Antistina). AUergy 1981 36(7) 517-19. 

Nifedipine has been reported to cause agranulocytosis (85) and leukopenia was attributed to diltiazem the latter patient had scleroderma, active rheumatoid disease, and pulmonary fibrosis, but the white cell count fell after 3 weeks of diltiazem, recovered on withdrawal, and fell on rechallenge (86). Diltiazem has also been reported to cause immune thrombocytopenia in a 68-year-old man with angina (87). 

Baggott LA. Diltiazem-associated immune thrombocytopenia. Mt Sinai J Med 1987 54(6) 500-4. 

Lown JA, Barr AL. Immune thrombocytopenia induced by cephalosporins specific for thiomethyltetrazole side chain. J Clin Pathol 1987 40(6) 700-1. 

Cranberry juice may contain small amounts of quinine, which can cause immune thrombocytopenia. 

Hegde UP, Wilson WH, White T, Cheson BD. Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia. Blood 2002 100(6) 2260-2. 

Fernandez MJ, Llopis I, Pastor E, Real E, Grau E. Immune thrombocytopenia induced by fludarabine successfully treated with rituximab. Haematologica 2003 88(2) ELT02. 

Ball S, Zuiable A, Roter BL, Hegde UM. Changes in platelet immunoprotein levels during therapy in adult immune thrombocytopenia. Br J Haematol 1985 60(4) 631-3. 

Auto-immune thrombocytopenia occurred in a patient receiving interferon gamma (SEDA-22, 406). 

Bougie D, Aster R. Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood 2001 97(12) 3846-50. 

This suggests that in patients with drug-induced immune thrombocytopenia, tests for metabolite-dependent antibodies can be helpful in identifying the responsible agent. 

Perez-Vazquez A, Pastor JM, Riancho JA. Immune thrombocytopenia caused by piperacillin/tazobactam. Clin Infect Dis I998 27(3) 650-I. 

Kelton JG. Vaccination-Associated relapse of immune thrombocytopenia. JAMA 1981 245(4) 369-70. 

Saleh MN, Dhodaphar N, Allen K, LoBuglio AF. Quinidine-induced immune thrombocytopenia. Henry Ford Hosp Med J 1989 37(l) 28-32. 

Immune thrombocytopenia during rifampicin therapy has been attributed to drug-dependent binding of an IgG antibody to platelets the binding epitope of the antibody was found in the glycoprotein Ib/IX complex (38). 

Pereira J, Hidalgo P, Ocqueteau M, Blacutt M, Marchesse M, Nien Y, Letelier L, Mezzano D. Glycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia. Br J Haematol 2000 110(4) 907-10. 

Kiefel V, Santoso S, Schmidt S, Salama A, Mueller-Eckhardt C. Metabolite-specific (IgG) and drug-specific antibodies (IgG, IgM) in two cases of trimethoprim-sulfamethoxazole-induced immune thrombocytopenia. Transfusion 1987 27(3) 262-5. 

Nagae S, Hori Y. Immune thrombocytopenia due to tranilast (Rizaben) detection of drug-dependent platelet-associated IgG. J Dermatol 1998 25(ll) 706-9. 

Immune thrombocytopenia caused by tranilast has been reported in a 17-year-old man. The drug was withdrawn and oral prednisolone was started. He recovered within 1 week. Antiplatelet antibodies were not detected, but there was a platelet-associated IgG, which increased... 

Barr AL, Whineray M. Immune thrombocytopenia induced by cotrimoxazole. Aust NZ1 Med 1980 10(l) 54-5. 

Hapten-mediated immune thrombocytopenia usually occurs at least 7 days after the initiation of the drug, although it may occur much sooner if the exposure is actually a re-exposure to a previously administered drug. It occurs frequently in patients receiving large doses of the medication (e.g., penicillin derivatives >150mg/kg). The recovery period, once the suspected drug is discontinued, is often short in duration. ... 

Greinacher A, Eichler P, Lubenow N, Kiefel V (2001) Drug-induced and drug-dependent immune thrombocytopenias. Rev Clin Exp Hematol, 5(3) 166-200, 311-312. 

Aplastic anemias (some forms) Complications of malignancy Hypercalcemia Hematologic malignancies Acute lymphoblastic leukemia Lymphomas Multiple myeloma Immune hemolytic anemia Immune thrombocytopenia Inflammatory bowel disease Transfusion reactions Allergic and Immune Diseases Acute hypersensitivity reactions Allergic rhinitis Anaphylaxis... 

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